PMID- 31642285
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20200108
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 37
IP  - 10
DP  - 2019 Oct 8
TI  - [Determination of chlorate and perchlorate in milk power by high-performance 
      liquid chromatography-tandem mass spectrometry].
PG  - 1064-1070
LID - 10.3724/SP.J.1123.2019.04052 [doi]
AB  - An analytical method based on high-performance liquid chromatography-tandem mass 
      spectrometry (HPLC-MS/MS) was developed for detecting chlorate and perchlorate 
      residues in milk power. Chlorate and perchlorate in milk power were extracted 
      using a 0.1% (v/v) formic acid-acetonitrile solution. The extract was centrifuged 
      at 10000 r/min for 10 min, and the supernatant was cleaned up on a PRiME HLB 
      column. Separation of chlorate and perchlorate was performed on an ion-exchange 
      column (Thermo Scientific Acclaim TRINITY P1, 50 mmx2.1 mm, 3 mum) by gradient 
      elution using acetonitrile and 20 mmol/L ammonium acetate solution as the mobile 
      phase. The analytes were identified by MS/MS. Quantification was achieved using 
      internal standards. Chlorate and perchlorate demonstrated good linearity in the 
      ranges of 2.0-40.0 and 1.0-20.0 mug/L, respectively, with correlation coefficients 
      (r(2)) greater than 0.999. The limits of quantification (LOQs) of chlorate and 
      perchlorate were found to be 15.0 and 7.5 mug/kg, respectively. The recoveries of 
      chlorate and perchlorate ranged from 89.24% to 107.85% at the three spike levels 
      of 30.0, 60.0, and 120.0, and 15.0, 30.0, and 60.0 mug/kg, respectively, with 
      relative standard deviations (RSDs) ranging from 3.15% to 10.42% (n=6). This 
      method is convenient, rapid, accurate, and efficient, thus demonstrating its 
      suitability for use in the determination of chlorate and perchlorate in milk 
      power.
FAU - Zhou, Xiaoqing
AU  - Zhou X
AD  - Jiang Xi Institute for Food Control, Nanchang 330001, China.
FAU - Lu, Xiaoli
AU  - Lu X
AD  - Jiang Xi Institute for Food Control, Nanchang 330001, China.
FAU - Wan, Jianchun
AU  - Wan J
AD  - Jiang Xi Institute for Food Control, Nanchang 330001, China.
FAU - Guo, Ping
AU  - Guo P
AD  - Jiang Xi Institute for Food Control, Nanchang 330001, China.
FAU - Guo, Dan
AU  - Guo D
AD  - Jiang Xi Institute for Food Control, Nanchang 330001, China.
FAU - Xi, Huiting
AU  - Xi H
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Chlorates)
RN  - 0 (Perchlorates)
SB  - IM
MH  - Animals
MH  - Chlorates/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Food Contamination/*analysis
MH  - Milk/*chemistry
MH  - Perchlorates/*analysis
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - chlorate
OT  - high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
OT  - milk power
OT  - perchlorate
EDAT- 2019/10/24 06:00
MHDA- 2019/10/28 06:00
CRDT- 2019/10/24 06:00
PHST- 2019/10/24 06:00 [entrez]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
AID - 10.3724/SP.J.1123.2019.04052 [doi]
PST - ppublish
SO  - Se Pu. 2019 Oct 8;37(10):1064-1070. doi: 10.3724/SP.J.1123.2019.04052.