PMID- 31642296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20191023
LR  - 20200108
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 37
IP  - 9
DP  - 2019 Sep 8
TI  - [Preparation and application of tilmicosin-templated magnetic surface molecularly 
      imprinted polymer].
PG  - 932-938
LID - 10.3724/SP.J.1123.2019.03005 [doi]
AB  - A novel magnetic surface molecularly imprinted adsorbent is described. 
      Fe(3)O(4)@SiO(2), tilmicosin, and methacrylic acid were chosen as the support 
      substrate, template molecule, and functional monomer, respectively. 
      3-Methacryloxypropyltrimethoxysilane was chemically bonded onto the surface of 
      Fe(3)O(4)@SiO(2) via a silanization reaction and used as the crosslinking agent 
      in the subsequent reaction. The obtained magnetic surface molecularly imprinted 
      polymer (MS-MIP) showed high selectivity and high enrichment capacity towards 
      macrolide antibiotics (MACs), as indicated by the 212-, 275-, 675-, and 293-fold 
      enrichment factors for spiramycin, josamycin, tilmicosin, and tylosin tartrate, 
      separately. Because of the marked cavities onto the surface of the MS-MIP, the 
      time required to reach adsorption equilibrium (30 min) was shorter than that for 
      traditional MIP sorbents. Moreover, the adsorbent could be reused at least 6 
      times. Finally, the MS-MIP was used in combination with high performance liquid 
      chromatography-ultraviolet detection (HPLC-UV) for the extraction and enrichment 
      of four MACs in milk powder samples. The limits of detection (LODs) and limits of 
      quantitation (LOQs) for the four MACs were in the range of 0.58-1.36 mug/kg and 
      1.92-4.55 mug/kg, respectively. The interday (n=5) and intraday (n=3) recoveries 
      were in the range of 83.2%-123.0% at three spiked levels of 80, 200, and 500 
      mug/kg, under all the experimental conditions employed, and the relative standard 
      deviations were less than 12.2%.
FAU - Xia, Zhangyueyi
AU  - Xia Z
AD  - Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of 
      Education, School of Pharmacy, East China University of Science and Technology, 
      Shanghai 200237, China.
FAU - Yang, Bingcheng
AU  - Yang B
AD  - Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of 
      Education, School of Pharmacy, East China University of Science and Technology, 
      Shanghai 200237, China.
FAU - Zhang, Feifang
AU  - Zhang F
AD  - Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of 
      Education, School of Pharmacy, East China University of Science and Technology, 
      Shanghai 200237, China.
FAU - Liang, Xinmiao
AU  - Liang X
AD  - Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of 
      Education, School of Pharmacy, East China University of Science and Technology, 
      Shanghai 200237, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
SB  - IM
OTO - NOTNLM
OT  - high performance liquid chromatography (HPLC)
OT  - macrolide antibiotics
OT  - magnetic solid phase extraction
OT  - milk powder
OT  - surface molecularly imprinted polymer
EDAT- 2019/10/24 06:00
MHDA- 2019/10/24 06:01
CRDT- 2019/10/24 06:00
PHST- 2019/10/24 06:00 [entrez]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2019/10/24 06:01 [medline]
AID - 10.3724/SP.J.1123.2019.03005 [doi]
PST - ppublish
SO  - Se Pu. 2019 Sep 8;37(9):932-938. doi: 10.3724/SP.J.1123.2019.03005.