PMID- 31642302
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20200108
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 37
IP  - 9
DP  - 2019 Sep 8
TI  - [Determination of ten alkaloids in cosmetics by high performance liquid 
      chromatography-tandem mass spectrometry].
PG  - 977-982
LID - 10.3724/SP.J.1123.2019.01054 [doi]
AB  - A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) 
      method was established for the determination of ten alkaloids in cosmetics. 
      Extraction conditions, purification methods and instrumental parameters were 
      optimized. The samples were ultrasonically extracted with 80% (v/v) methanol 
      aqueous solution. The extracts were separated and filtered after centrifugation. 
      The analytes were separated on a Waters BEH C(18) column, and detected in the 
      selected reaction monitoring mode. Ten alkaloids were quantified by the external 
      standard method. The ten alkaloids showed good linearity with correlation 
      coefficients (R(2)) greater than 0.9900. The limits of detection (LODs) and the 
      limits of quantification (LOQs) of the ten alkaloids were in range of 5.0-12.5 
      mug/kg and 12.5-50.0 mug/kg, respectively. The average spiked recoveries in the 
      cosmetics ranged from 70.91% to 116.75%, and the relative standard deviations 
      (RSDs) ranged from 0.49% to 9.98%. The method can be used for the rapid screening 
      and quantitative analysis of ten alkaloids in cosmetics.
FAU - Cao, Meirong
AU  - Cao M
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
FAU - Ma, Junmei
AU  - Ma J
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
FAU - Wang, Juan
AU  - Wang J
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
FAU - Zhai, Hongwen
AU  - Zhai H
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
FAU - Zhao, Xiaoya
AU  - Zhao X
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
FAU - Fan, Sufang
AU  - Fan S
AD  - Hebei Food Inspection and Research Institute, Hebei Food Safety Key Laboratory, 
      Shijiazhuang 050091, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Alkaloids)
RN  - 0 (Cosmetics)
SB  - IM
MH  - Alkaloids/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Cosmetics/*analysis
MH  - Limit of Detection
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - alkaloids
OT  - cosmetics
OT  - high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
EDAT- 2019/10/24 06:00
MHDA- 2019/10/28 06:00
CRDT- 2019/10/24 06:00
PHST- 2019/10/24 06:00 [entrez]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
AID - 10.3724/SP.J.1123.2019.01054 [doi]
PST - ppublish
SO  - Se Pu. 2019 Sep 8;37(9):977-982. doi: 10.3724/SP.J.1123.2019.01054.