PMID- 31642969
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20211204
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 34
IP  - 11
DP  - 2019 Nov
TI  - Epidemiology of and prognostic factors for appendiceal carcinomas: a 
      retrospective, population-based study.
PG  - 1915-1924
LID - 10.1007/s00384-019-03387-y [doi]
AB  - BACKGROUND: The aim of this study is to evaluate the epidemiology of and 
      prognostic factors for appendiceal carcinomas (ACs). METHODS: All cases of ACs 
      registered in the Surveillance, Epidemiology, and End Results (SEER) database 
      from 1973 to 2014 were retrospectively identified in this study. Age-adjusted 
      incidence and survival rates were calculated. RESULTS: We analyzed 7170 patients 
      with ACs. We observed a significant increase in the reported annual age-adjusted 
      incidence of ACs from 1973 (0.18/100,000) to 2014 (1.11/100,000). The elevation 
      of the incidence was noted in all the histological types, stages, and grades. The 
      most common histological type varied by race, with the appendiceal mucinous 
      adenocarcinoma (AMA) being the most common in white, Asian/Pacific Islander, and 
      American Indian/Alaskan Native patients, and the appendiceal adenocarcinoma (AA) 
      being the most common in African American patients. In multivariate analysis of 
      patients with all ACs, gender (P < 0.001), year of diagnosis (P < 0.001), age 
      (P < 0.001), race (P < 0.001), tumor grade (P < 0.001), disease stage 
      (P < 0.001), retrieved regional lymph nodes (P < 0.001), type of surgery 
      performed (P = 0.002), and histologic subtype (P < 0.001) were predictors of 
      outcome. Survival time for all ACs increased from the 1973-1993 period to the 
      1994-2014 period (HR 0.76; 95% CI, 0.69 to 0.85). Additionally, the 5-year 
      survival rates were 88% for malignant carcinoid, 70% for goblet cell carcinoid, 
      51% for colonic type adenocarcinoma, 59% for mucinous adenocarcinoma, and 25% for 
      signet ring cell type. CONCLUSIONS: We observed increased reported incidence of 
      ACs and increased survival durations over time, suggesting that clinicians pay 
      more attention to ACs and mastering the characteristic of these tumors.
FAU - Mo, Shaobo
AU  - Mo S
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Zhou, Zheng
AU  - Zhou Z
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Ying, Zhen
AU  - Ying Z
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Dai, Weixing
AU  - Dai W
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Xiang, Wenqiang
AU  - Xiang W
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Han, Lingyu
AU  - Han L
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Li, Qingguo
AU  - Li Q
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China.
FAU - Wang, Renjie
AU  - Wang R
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China. wangbladejay@sina.com.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China. wangbladejay@sina.com.
FAU - Cai, Guoxiang
AU  - Cai G
AUID- ORCID: 0000-0003-2953-3460
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 
      Shanghai, 200032, China. gxcaifuscc@163.com.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an 
      Road, Shanghai, 200032, China. gxcaifuscc@163.com.
LA  - eng
PT  - Journal Article
DEP - 20191023
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
SB  - IM
MH  - Adult
MH  - Aged
MH  - Appendiceal Neoplasms/diagnosis/*epidemiology/pathology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Racial Groups
MH  - Retrospective Studies
MH  - SEER Program
MH  - Survival Analysis
OTO - NOTNLM
OT  - Appendiceal carcinoma
OT  - Epidemiology
OT  - Incidence
OT  - Prognostic factors
OT  - Survival outcomes
EDAT- 2019/10/24 06:00
MHDA- 2020/04/03 06:00
CRDT- 2019/10/24 06:00
PHST- 2019/09/01 00:00 [accepted]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2019/10/24 06:00 [entrez]
AID - 10.1007/s00384-019-03387-y [pii]
AID - 10.1007/s00384-019-03387-y [doi]
PST - ppublish
SO  - Int J Colorectal Dis. 2019 Nov;34(11):1915-1924. doi: 10.1007/s00384-019-03387-y. 
      Epub 2019 Oct 23.