PMID- 31643092
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 235
IP  - 5
DP  - 2020 May
TI  - BZW2 promotes the malignant progression of colorectal cancer via activating the 
      ERK/MAPK pathway.
PG  - 4834-4842
LID - 10.1002/jcp.29361 [doi]
AB  - Colorectal cancer (CRC) is one of the most prevalent malignant solid cancers 
      worldwide involving the dysregulation of multiple signaling molecules. However, 
      the role and corresponding mechanism of basic leucine zipper and W2 domains 2 
      (BZW2) in CRC development, to our knowledge, has not been reported. We found BZW2 
      was overexpressed in human CRC tissues compared with that in paired adjacent 
      colorectal samples. BZW2 overexpression was closely associated with tumor T stage 
      (p = .030), metastatic lymph nodes (p = .037), TNM stage (p = .018) and the worse 
      prognosis of CRC patients (p = .009). Moreover, BZW2 was an independent 
      disadvantage prognostic factor (p = .031). BZW2 also showed an increased 
      expression in different invasive CRC cell lines. Its silencing and overexpression 
      diminished and increased cell proliferation, invasion, and migration in Colo205 
      and HCT116 cells via specifically activating of extracellular-signal-regulated 
      kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling. Moreover, 
      ERK/MAPK inhibitor PD98059 reverse the enhancement of cell proliferation, 
      invasion, and migration in BZW2 overexpressing HCT116 cells. BZW2 silencing also 
      inhibited subcutaneous tumors growth and p-ERK expression in vivo. BZW2 promotes 
      the malignant progression of CRC via activating ERK/MAPK signaling, which 
      provided a promising gene target therapy for CRC.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Huang, Longping
AU  - Huang L
AD  - Department of General and Hepatobiliary Surgery, The Fourth People's Hospital of 
      Shenyang city, Shenyang, China.
FAU - Chen, Si
AU  - Chen S
AD  - Department of Anesthesiology, The Fourth People's Hospital of Shenyang city, 
      Shenyang, China.
FAU - Fan, Haijun
AU  - Fan H
AD  - Department of General and Hepatobiliary Surgery, The Fourth People's Hospital of 
      Shenyang city, Shenyang, China.
FAU - Ai, Fan
AU  - Ai F
AD  - Department of General and Hepatobiliary Surgery, The Fourth People's Hospital of 
      Shenyang city, Shenyang, China.
FAU - Sheng, Weiwei
AU  - Sheng W
AUID- ORCID: 0000-0003-2311-7140
AD  - Department of Gastrointestinal Surgery, The First Hospital, China Medical 
      University, Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20191023
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Antineoplastic Agents)
RN  - 0 (BZW2 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Colorectal Neoplasms/*enzymology/genetics/pathology/therapy
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/*metabolism
MH  - Female
MH  - Gene Silencing
MH  - HCT116 Cells
MH  - Humans
MH  - Male
MH  - Mice, Nude
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Signal Transduction
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - ERK
OT  - basic leucine zipper and W2 domains 2
OT  - colorectal cancer
EDAT- 2019/10/24 06:00
MHDA- 2021/03/09 06:00
CRDT- 2019/10/24 06:00
PHST- 2019/06/17 00:00 [received]
PHST- 2019/10/07 00:00 [accepted]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2019/10/24 06:00 [entrez]
AID - 10.1002/jcp.29361 [doi]
PST - ppublish
SO  - J Cell Physiol. 2020 May;235(5):4834-4842. doi: 10.1002/jcp.29361. Epub 2019 Oct 
      23.