PMID- 31646090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 8
IP  - 11
DP  - 2019
TI  - Sepsis inhibits tumor growth in mice with cancer through Toll-like receptor 
      4-associated enhanced Natural Killer cell activity.
PG  - e1641391
LID - 10.1080/2162402X.2019.1641391 [doi]
LID - e1641391
AB  - Sepsis-induced immune dysfunctions are likely to impact on malignant tumor 
      growth. Sequential sepsis-then-cancer models of tumor transplantation in mice 
      recovering from sepsis have shown that the post-septic immunosuppressive 
      environment was able to promote tumor growth. We herein addressed the impact of 
      sepsis on pre-established malignancy in a reverse cancer-then sepsis experimental 
      model. Mice previously inoculated with MCA205 fibrosarcoma cells were subjected 
      to septic challenges by polymicrobial peritonitis induced by cecal ligation and 
      puncture or endotoxinic shock. The anti-tumoral immune response was assessed 
      through the distribution of tumor-infiltrating immune cells, as well as the 
      functions of cytotoxic cells. As compared to sham surgery, polymicrobial sepsis 
      dampened malignant tumor growth in wild-type (WT) mice, but neither in Toll-like 
      receptor 4 (Tlr4)(-/-) nor in Myd88(-/-) mice. Similar tumor growth inhibition 
      was observed following a LPS challenge in WT mice, suggesting a regulatory role 
      of Tlr4 in this setting. The low expression of MHC class 1 onto MCA205 cells 
      suggested the involvement of Natural Killer (NK) cells in sepsis-induced tumor 
      inhibition. Septic insults applied to mice with cancer promoted the main 
      anti-tumoral NK functions of IFNgamma production and degranulation. The anti-tumoral 
      properties of NK cells obtained from septic mice were exacerbated when cultured 
      with MHC1(low) MCA205 or YAC-1 cells. These results suggest that sepsis may 
      harbor dual effects on tumor growth depending on the sequential experimental 
      model. When applied in mice with cancer, sepsis prevents tumor growth in a 
      Tlr4-dependent manner by enhancing the anti-tumoral functions of NK cells.
CI  - (c) 2019 Taylor & Francis Group, LLC.
FAU - Vigneron, Clara
AU  - Vigneron C
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Mirouse, Adrien
AU  - Mirouse A
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Merdji, Hamid
AU  - Merdji H
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Rousseau, Christophe
AU  - Rousseau C
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Cousin, Clement
AU  - Cousin C
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Alby-Laurent, Fanny
AU  - Alby-Laurent F
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Mira, Jean-Paul
AU  - Mira JP
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
AD  - Medecine Intensive & Reanimation, hopital Cochin, Hopitaux Universitaires Paris 
      Centre, Assistance Publique - Hopitaux de Paris, Paris, France.
FAU - Chiche, Jean-Daniel
AU  - Chiche JD
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
AD  - Medecine Intensive & Reanimation, hopital Cochin, Hopitaux Universitaires Paris 
      Centre, Assistance Publique - Hopitaux de Paris, Paris, France.
FAU - Llitjos, Jean-Francois
AU  - Llitjos JF
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
AD  - Medecine Intensive & Reanimation, hopital Cochin, Hopitaux Universitaires Paris 
      Centre, Assistance Publique - Hopitaux de Paris, Paris, France.
FAU - Pene, Frederic
AU  - Pene F
AD  - Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
AD  - Medecine Intensive & Reanimation, hopital Cochin, Hopitaux Universitaires Paris 
      Centre, Assistance Publique - Hopitaux de Paris, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190719
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC6791422
OTO - NOTNLM
OT  - Natural Killer
OT  - Sepsis
OT  - Toll-like receptor 4
OT  - cancer
EDAT- 2019/10/28 06:00
MHDA- 2019/10/28 06:01
PMCR- 2020/07/19
CRDT- 2019/10/25 06:00
PHST- 2019/02/04 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/07/03 00:00 [accepted]
PHST- 2019/10/25 06:00 [entrez]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2019/10/28 06:01 [medline]
PHST- 2020/07/19 00:00 [pmc-release]
AID - 1641391 [pii]
AID - 10.1080/2162402X.2019.1641391 [doi]
PST - epublish
SO  - Oncoimmunology. 2019 Jul 19;8(11):e1641391. doi: 10.1080/2162402X.2019.1641391. 
      eCollection 2019.