PMID- 31648110
OWN - NLM
STAT- MEDLINE
DCOM- 20200922
LR  - 20240422
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 111
DP  - 2020 Jan
TI  - Environmental enrichment improves metabolic and behavioral health in the BTBR 
      mouse model of autism.
PG  - 104476
LID - S0306-4530(19)30565-7 [pii]
LID - 10.1016/j.psyneuen.2019.104476 [doi]
AB  - BTBR T + Itpr3tf/J (BTBR) mice are an Autism Spectrum Disorder (ASD)-like model 
      that exhibit behavioral and physiological deficits similar to those observed in 
      patients with ASD. While behavioral therapy is a first line of treatment in ASD 
      patients, comparable non-pharmacological treatments are less explored in murine 
      models. Here, we administer a bio-behavioral intervention for BTBR mice by way of 
      environmental enrichment (EE) - an experimental housing paradigm previously shown 
      to improve systemic metabolism, learning/memory, anxious behavior, neurogenesis, 
      locomotion, and immunocompetence in C57BL/6 mice. Juvenile BTBR mice were 
      randomized to standard or EE housing and were subjected to metabolic and 
      behavioral assessments up to 17 weeks. Following EE exposure, we report an 
      EE-induced metabolic and behavioral phenotype. Male BTBR mice responded 
      metabolically to EE, displaying reduced adiposity, increased lean mass, improved 
      glycemic control, and decreased circulating leptin. The gene expressions of 
      brain-derived neurotrophic factor (Bdnf) and its receptor (Ntrk2/TrkB) were 
      upregulated in several brain areas in EE-BTBR males. EE-BTBR females showed 
      modest reduction of adiposity and no changes in glycemic control, circulating 
      leptin, or Bdnf/Ntrk2 gene expression. With regard to behavior, EE resulted in 
      decreased anxiety, and increased social affiliation. Together, these results 
      suggest that EE improves metabolic and behavioral health in BTBR mice.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Queen, Nicholas J
AU  - Queen NJ
AD  - Department of Cancer Biology and Genetics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA; The Ohio State University Comprehensive 
      Cancer Center, Columbus, OH 43210, USA.
FAU - Boardman, Amber A
AU  - Boardman AA
AD  - Department of Cancer Biology and Genetics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA; The Ohio State University Comprehensive 
      Cancer Center, Columbus, OH 43210, USA.
FAU - Patel, Ripal S
AU  - Patel RS
AD  - Department of Cancer Biology and Genetics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA; The Ohio State University Comprehensive 
      Cancer Center, Columbus, OH 43210, USA.
FAU - Siu, Jason J
AU  - Siu JJ
AD  - Department of Cancer Biology and Genetics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA; The Ohio State University Comprehensive 
      Cancer Center, Columbus, OH 43210, USA.
FAU - Mo, Xiaokui
AU  - Mo X
AD  - Department of Biomedical Informatics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA.
FAU - Cao, Lei
AU  - Cao L
AD  - Department of Cancer Biology and Genetics, College of Medicine, The Ohio State 
      University, Columbus, OH 43210, USA; The Ohio State University Comprehensive 
      Cancer Center, Columbus, OH 43210, USA. Electronic address: Lei.Cao@osumc.edu.
LA  - eng
GR  - R01 CA163640/CA/NCI NIH HHS/United States
GR  - R01 CA166590/CA/NCI NIH HHS/United States
GR  - R21 CA178227/CA/NCI NIH HHS/United States
GR  - R01 AG041250/AG/NIA NIH HHS/United States
GR  - R56 AG041250/AG/NIA NIH HHS/United States
GR  - P30 NS104177/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20191015
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - Autism Spectrum Disorder/metabolism/physiopathology/therapy
MH  - Autistic Disorder/*metabolism/*physiopathology/*therapy
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Disease Models, Animal
MH  - Environment
MH  - Female
MH  - Male
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Protein-Tyrosine Kinases/genetics/metabolism
MH  - Social Behavior
PMC - PMC6914218
MID - NIHMS1546002
OTO - NOTNLM
OT  - Autism spectrum disorder
OT  - BDNF
OT  - BTBR mice
OT  - Environmental enrichment
OT  - Metabolism
OT  - Sociability
OT  - TrkB
COIS- CONFLICTS OF INTEREST The authors declare no competing financial interests.
EDAT- 2019/10/28 06:00
MHDA- 2020/09/23 06:00
PMCR- 2021/01/01
CRDT- 2019/10/25 06:00
PHST- 2019/06/10 00:00 [received]
PHST- 2019/09/20 00:00 [revised]
PHST- 2019/10/09 00:00 [accepted]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2020/09/23 06:00 [medline]
PHST- 2019/10/25 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - S0306-4530(19)30565-7 [pii]
AID - 10.1016/j.psyneuen.2019.104476 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2020 Jan;111:104476. doi: 
      10.1016/j.psyneuen.2019.104476. Epub 2019 Oct 15.