PMID- 31648725
OWN - NLM
STAT- MEDLINE
DCOM- 20200130
LR  - 20200130
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 238
DP  - 2019 Nov
TI  - Therapeutic effect of Xanthohumol against highly pathogenic porcine reproductive 
      and respiratory syndrome viruses.
PG  - 108431
LID - S0378-1135(19)31036-3 [pii]
LID - 10.1016/j.vetmic.2019.108431 [doi]
AB  - The infection by porcine reproductive and respiratory syndrome virus (PRRSV) has 
      a severe impact on the world swine industry. However, commercially available 
      vaccines provide only incomplete protection against this disease. Thus, novel 
      approaches to control PRRSV infection are essential for the robust and 
      sustainable swine industry. In our previous study, Xanthohumol (Xn), a prenylated 
      flavonoid extracted for hops (Humulus lupulus L), was screened from 386 natural 
      products to inhibit PRRSV proliferation and alleviate oxidative stress induced by 
      PRRSV via the Nrf2-HMOX1 axis in Marc-145 cells. In this study, we furtherly 
      found that Xn could inhibit PRRSV different sub-genotype strains infection with a 
      low IC(50) value in porcine primary alveolar macrophages (PAMs). In addition, it 
      caused decreased expression of interleukin (IL)-1beta, IL-6, IL-8, and tumor 
      necrosis factor-alpha in PAMs infected with PRRSV or treated with lipopolysaccharide. 
      Animal challenge experiments showed that Xn effectively alleviated clinical 
      signs, lung pathology, and inflammatory responses in lung tissues of pigs induced 
      by highly pathogenic PRRSV infection. The results demonstrate that Xn is a 
      promising therapeutic agent to combat PRRSV infections.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Liu, Xuewei
AU  - Liu X
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China.
FAU - Bai, Juan
AU  - Bai J
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China.
FAU - Jiang, Chenlong
AU  - Jiang C
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China.
FAU - Song, Zhongbao
AU  - Song Z
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China.
FAU - Zhao, Yongxiang
AU  - Zhao Y
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China.
FAU - Nauwynck, Hans
AU  - Nauwynck H
AD  - Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, 
      Salisburylaan 133, B-9820 Merelbeke Merelbeke, Belgium.
FAU - Jiang, Ping
AU  - Jiang P
AD  - Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of 
      Agriculture, MOE International Joint Collaborative Research Laboratory for Animal 
      Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural 
      University, Nanjing, 210095, China; Jiangsu Co-innovation Center for Prevention 
      and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 
      China. Electronic address: jiangp@njau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190926
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antiviral Agents)
RN  - 0 (Biological Products)
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (Propiophenones)
RN  - T4467YT1NT (xanthohumol)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/pharmacology/therapeutic use
MH  - Biological Products/pharmacology
MH  - Cytokines/genetics
MH  - Flavonoids/*pharmacology/*therapeutic use
MH  - Gene Expression Regulation/drug effects
MH  - Genotype
MH  - Inhibitory Concentration 50
MH  - Lung/drug effects
MH  - Macrophages, Alveolar/drug effects/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*drug therapy
MH  - Porcine respiratory and reproductive syndrome virus/*drug effects
MH  - Propiophenones/*pharmacology/*therapeutic use
MH  - Swine
OTO - NOTNLM
OT  - Antiviral activity
OT  - PRRSV
OT  - Xanthohumol
EDAT- 2019/10/28 06:00
MHDA- 2020/01/31 06:00
CRDT- 2019/10/26 06:00
PHST- 2019/08/30 00:00 [received]
PHST- 2019/09/25 00:00 [revised]
PHST- 2019/09/25 00:00 [accepted]
PHST- 2019/10/26 06:00 [entrez]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2020/01/31 06:00 [medline]
AID - S0378-1135(19)31036-3 [pii]
AID - 10.1016/j.vetmic.2019.108431 [doi]
PST - ppublish
SO  - Vet Microbiol. 2019 Nov;238:108431. doi: 10.1016/j.vetmic.2019.108431. Epub 2019 
      Sep 26.