PMID- 31648932
OWN - NLM
STAT- MEDLINE
DCOM- 20200508
LR  - 20200508
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 167
IP  - 2
DP  - 2020 Feb
TI  - Ligation of intersphincteric fistula tract (LIFT) in treatment of anal fistula: 
      An updated systematic review, meta-analysis, and meta-regression of the 
      predictors of failure.
PG  - 484-492
LID - S0039-6060(19)30668-3 [pii]
LID - 10.1016/j.surg.2019.09.012 [doi]
AB  - BACKGROUND: Ligation of intersphincteric fistula tract has gained increasing 
      popularity as a sphincter-sparing technique for complex anal fistula. The present 
      review aimed to investigate the pooled success and complication rates of ligation 
      of intersphincteric fistula tract in the published literature and to explore the 
      risk factors for failure after ligation of intersphincteric fistula tract. 
      METHODS: A Preferred Reporting Items for Systematic Reviews and 
      Meta-Analyses-compliant literature search was conducted. Electronic databases 
      were searched in the period of January 2007 through April 2019 for studies that 
      assessed the outcome of the ligation of intersphincteric fistula tract procedure. 
      The main outcomes of the review were the pooled success and complication rates of 
      ligation of intersphincteric fistula tract, predictors of failure after ligation 
      of intersphincteric fistula tract, operation time, hospital stay, and how 
      failures were managed. RESULTS: Twenty-six studies comprising 1,378 patients (996 
      male) were included in this review. The mean age of patients was 42.3 +/- 4.2 
      years. The weighted mean rate of success was 76.5%. The median follow-up duration 
      was 16.5 months. The weighted mean complication rate was 13.9%. The most common 
      complication was wound dehiscence. Fecal incontinence was recorded in 1.4% of 
      patients. Factors that were statistically significantly associated with failure 
      after the ligation of intersphincteric fistula tract procedure were horseshoe 
      fistulas, fistulas associated with Crohn's disease, and those with a history of 
      previous fistula surgery. CONCLUSION: The pooled success and complication rates 
      of the ligation of intersphincteric fistula tract procedure were about 76% and 
      14%, respectively. Horseshoe fistulas, Crohn's disease, and previous fistula 
      surgery were identified as predictors for failure after ligation of 
      intersphincteric fistula tract procedure.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Emile, Sameh Hany
AU  - Emile SH
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, Egypt. Electronic address: Sameh200@hotmail.com.
FAU - Khan, Sualeh Muslim
AU  - Khan SM
AD  - Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
FAU - Adejumo, Adeyinka
AU  - Adejumo A
AD  - Division of General Surgery, Department of Surgery, Federal Medical Center, 
      Keffi, Nigeria.
FAU - Koroye, Oyintonbra
AU  - Koroye O
AD  - Department of Surgery, Niger Delta University, Amassoma, Nigeria.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191021
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Humans
MH  - Postoperative Complications/epidemiology
MH  - Rectal Fistula/*surgery
MH  - Recurrence
MH  - Treatment Failure
EDAT- 2019/10/28 06:00
MHDA- 2020/05/10 06:00
CRDT- 2019/10/26 06:00
PHST- 2019/07/05 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/09/11 00:00 [accepted]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2020/05/10 06:00 [medline]
PHST- 2019/10/26 06:00 [entrez]
AID - S0039-6060(19)30668-3 [pii]
AID - 10.1016/j.surg.2019.09.012 [doi]
PST - ppublish
SO  - Surgery. 2020 Feb;167(2):484-492. doi: 10.1016/j.surg.2019.09.012. Epub 2019 Oct 
      21.