PMID- 31651935
OWN - NLM
STAT- MEDLINE
DCOM- 20200925
LR  - 20200925
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 11
DP  - 2019 Nov 29
TI  - Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular 
      smooth muscle cell apoptosis and MMPs production.
LID - 10.1042/BSR20191252 [doi]
LID - BSR20191252
AB  - Abdominal aortic aneurysm (AAA) is often clinically silent before rupture 
      characterized by extensive vascular inflammation and degenerative elasticity of 
      aortic wall. Monocyte chemotactic protein-induced protein-1 (MCPIP1) exhibits 
      anti-infllammatory and pro-apoptotic effects involved in atherogenesis. However, 
      little is known about the expression and the contribution of MCPIP1 in AAA. In 
      the present study, we collected clinical AAA specimens and constructed AAA mice 
      model through Ang-II infusion, and found apparently increased MCPIP1 expression 
      and severe inflammatory infiltration in AAA aortic membrane as evidenced by 
      elevated levels of monocyte chemotactic protein 1 (MCP-1), interleukin 1 beta 
      (IL-1beta) and NF-kappaB, as well as HE staining. The elasticity of aortic tunica media 
      was impaired along with multiple apoptosis of vascular smooth muscle cells 
      (VSMCs) in Ang-II-induced aneurysmal mouse. In vitro Ang-II administration of 
      VSMCs induced MCPIP1 expression, accompanied by up-regulation of matrix 
      metalloproteinase (MMP) 2 (MMP-2) and MMP-9, as well as enhancement of VSMCs 
      proliferation and apoptosis, which may cause damage of intima-media elasticity. 
      Silencing MCPIP1 reversed above effects to further restore the balance of 
      proliferation and apoptosis in VSMCs. Overall, our data indicated that 
      up-regulation of MCPIP1 may become a promising candidate for the diagnosis of 
      AAA, and specific knockdown of MCPIP1 in VSMCs could inhibit VSMCs apoptosis and 
      down-regulate MMPs to maintain vascular wall elasticity. Therefore, knockdown of 
      MCPIP1 may serve as a potential target for gene therapy of AAA.
CI  - (c) 2019 The Author(s).
FAU - Xue, Ming
AU  - Xue M
AD  - Department of Vascular Surgery, Shandong Provincial Hospital affiliated to 
      Shandong University, Jinan 250021, Shandong, China.
AD  - Department of Interventional Radiology, Weihai Municipal Hospital, Weihai 264200, 
      Shandong, China.
FAU - Li, Gang
AU  - Li G
AD  - Office of the Director, Weihai Municipal Hospital, Weihai 264200, Shandong, 
      China.
FAU - Li, Dan
AU  - Li D
AD  - Department of Clinical Laboratory, Weihai Municipal Hospital, Weihai 264200, 
      Shandong, China.
FAU - Wang, Zhu
AU  - Wang Z
AD  - Department of Interventional Medicine and Vascular Surgery, The Affiliated 
      Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China.
FAU - Mi, Lei
AU  - Mi L
AD  - Department of General Surgery, Taian City Central Hospital, Taian 271000, 
      Shandong, China.
FAU - Da, Jingjing
AU  - Da J
AD  - Department of Biomedical Science, Guizhou University Medical College, Guiyang 
      550000, Guizhou, China.
FAU - Jin, Xing
AU  - Jin X
AD  - Department of Vascular Surgery, Shandong Provincial Hospital affiliated to 
      Shandong University, Jinan 250021, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factors)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.1.- (Ribonucleases)
RN  - EC 3.1.- (ZC3H12A protein, human)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Aorta/drug effects/metabolism
MH  - Aortic Aneurysm, Abdominal/*genetics
MH  - Apoptosis/drug effects/*genetics
MH  - Cell Proliferation/genetics
MH  - Down-Regulation/drug effects/genetics
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinases/*genetics
MH  - Mice
MH  - Muscle, Smooth, Vascular/drug effects/*metabolism
MH  - Myocytes, Smooth Muscle/drug effects/*metabolism
MH  - NF-kappa B/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ribonucleases/*genetics
MH  - Signal Transduction/drug effects/genetics
MH  - Transcription Factors/*genetics
MH  - Transcriptional Activation/drug effects/genetics
MH  - Up-Regulation/*genetics
PMC - PMC6851509
OTO - NOTNLM
OT  - Abdominal aortic aneurysm
OT  - MCPIP1
OT  - MMP
OT  - VSMCs
OT  - apoptosis
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/10/28 06:00
MHDA- 2020/09/26 06:00
PMCR- 2019/11/12
CRDT- 2019/10/26 06:00
PHST- 2019/04/28 00:00 [received]
PHST- 2019/09/24 00:00 [revised]
PHST- 2019/10/08 00:00 [accepted]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2020/09/26 06:00 [medline]
PHST- 2019/10/26 06:00 [entrez]
PHST- 2019/11/12 00:00 [pmc-release]
AID - 220754 [pii]
AID - BSR20191252 [pii]
AID - 10.1042/BSR20191252 [doi]
PST - ppublish
SO  - Biosci Rep. 2019 Nov 29;39(11):BSR20191252. doi: 10.1042/BSR20191252.