PMID- 31653043
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 11
IP  - 11
DP  - 2019 Oct 24
TI  - Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in 
      Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines.
LID - 10.3390/cancers11111640 [doi]
LID - 1640
AB  - Oleocanthal and ligstroside aglycone are olive oil-derived polyphenols. The 
      former interferes with tumor growth with minor or no cytotoxicity on 
      non-tumorigenic primary cell lines. The information about the bioactivity of 
      ligstroside aglycone are scanty, with the exception of a known antioxidant power. 
      Hepatocellular carcinoma is a malignant tumor with high mortality rates. Systemic 
      chemotherapy is only marginally effective and is frequently complicated by 
      toxicity. Previous observations have shown that hepatocellular carcinoma cell 
      lines become more sensitive to taxol when it is combined with Tumor Necrosis 
      Factor alpha (TNFalpha). The present work aimed to assess the effects of a polyphenolic 
      extract containing both oleocanthal and ligstroside aglycone on proliferation 
      and/or death in three liver cancer cell lines (HepG2, Huh7 and Hep3B). The 
      possibility to enhance such effect by the addition of TNFalpha was also investigated. 
      Both cell proliferation and death were enhanced by the exposure to the 
      polyphenolic extract. Such effect was associated with induction of autophagy and 
      could be potentiated by TNFalpha. The presence of ligstroside aglycone in the extract 
      lowered the oleocanthal concentration required for cytotoxicity. These results 
      show for the first time that the effects of a polyphenol extract can be 
      potentiated by TNFalpha and that modulation of autophagy likely account for these 
      effects.
FAU - De Stefanis, Daniela
AU  - De Stefanis D
AD  - Department of Clinical and Biological Sciences, Experimental Medicine and 
      Clinical Pathology Unit, University of Turin, 10125 Torino, Italy. 
      daniela.destefanis@unito.it.
FAU - Scime, Salvatore
AU  - Scime S
AD  - Department of Clinical and Biological Sciences, Experimental Medicine and 
      Clinical Pathology Unit, University of Turin, 10125 Torino, Italy. 
      scime.salvatore@gmail.com.
FAU - Accomazzo, Simone
AU  - Accomazzo S
AD  - Department of Clinical and Biological Sciences, Experimental Medicine and 
      Clinical Pathology Unit, University of Turin, 10125 Torino, Italy. 
      simone.accomazzo@gmail.com.
FAU - Catti, Andrea
AU  - Catti A
AD  - Department of Clinical and Biological Sciences, Experimental Medicine and 
      Clinical Pathology Unit, University of Turin, 10125 Torino, Italy. 
      andrea.catti@tiscali.it.
FAU - Occhipinti, Andrea
AU  - Occhipinti A
AD  - Department of Life Sciences and Systems Biology, University of Turin, 10125 
      Torino, Italy. a.occhipinti@abelnutraceuticals.com.
FAU - Bertea, Cinzia Margherita
AU  - Bertea CM
AD  - Department of Life Sciences and Systems Biology, University of Turin, 10125 
      Torino, Italy. cinzia.bertea@unito.it.
FAU - Costelli, Paola
AU  - Costelli P
AD  - Department of Clinical and Biological Sciences, Experimental Medicine and 
      Clinical Pathology Unit, University of Turin, 10125 Torino, Italy. 
      paola.costelli@unito.it.
LA  - eng
PT  - Journal Article
DEP - 20191024
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC6896128
OTO - NOTNLM
OT  - TNF alpha
OT  - autophagy
OT  - cell death
OT  - cell proliferation
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2019/10/28 06:00
MHDA- 2019/10/28 06:01
PMCR- 2019/10/24
CRDT- 2019/10/27 06:00
PHST- 2019/07/26 00:00 [received]
PHST- 2019/10/18 00:00 [revised]
PHST- 2019/10/21 00:00 [accepted]
PHST- 2019/10/27 06:00 [entrez]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2019/10/28 06:01 [medline]
PHST- 2019/10/24 00:00 [pmc-release]
AID - cancers11111640 [pii]
AID - cancers-11-01640 [pii]
AID - 10.3390/cancers11111640 [doi]
PST - epublish
SO  - Cancers (Basel). 2019 Oct 24;11(11):1640. doi: 10.3390/cancers11111640.