PMID- 31656544
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 18
IP  - 5
DP  - 2019 Nov
TI  - Salidroside prevents tumor necrosis factor-alpha-induced vascular inflammation by 
      blocking mitogen-activated protein kinase and NF-kappaB signaling activation.
PG  - 4137-4143
LID - 10.3892/etm.2019.8064 [doi]
AB  - Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. 
      Salidroside is an important active ingredient extracted from the root of the 
      Rhodiola rosea plant, which has been reported to have antioxidative, anti-cancer, 
      neuroprotective and cardioprotective effects. However, the effects of salidroside 
      on vascular inflammation have not been clarified. The purpose of the present 
      study was to investigate the protective effects of salidroside against tumor 
      necrosis factor (TNF)-alpha-induced vascular inflammation in cardiac microvascular 
      endothelial cells (CMECs), a specific cell type derived from coronary 
      micro-vessels. Over a 24-h period, salidroside did not exert any significant 
      cytotoxicity up to a dose of 100 microM. Additionally, salidroside decreased the 
      expression levels of the cell adhesion molecule vascular cell adhesion molecule-1 
      (VCAM-1) in TNF-alpha-stimulated CMECs, thus suppressing monocyte-to-CMEC adhesion. 
      Salidroside also decreased the production of inflammatory cytokines such as 
      interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein 1 (MCP-1) in 
      TNF-alpha-induced CMECs, as well as suppressing TNF-alpha-activated mitogen-activated 
      protein kinase (MAPK) and NF-kappaB activation. Since MAPKs and NF-kappaB both serve 
      notable roles in regulating the expression of VCAM-1, IL-1beta, IL-6 and MCP-1, the 
      present study provided a preliminary understanding of the mechanism underlying 
      the protective effects of salidroside. Overall, salidroside alleviated vascular 
      inflammation by mediating MAPK and NF-kappaB activation in TNF-alpha-induced CMECs. These 
      results indicated that salidroside may have potential applications as a 
      therapeutic agent against vascular inflammation and atherosclerosis.
CI  - Copyright (c) 2019, Spandidos Publications.
FAU - Li, Ruoshui
AU  - Li R
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Dong, Zhen
AU  - Dong Z
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      P.R. China.
FAU - Zhuang, Xinyu
AU  - Zhuang X
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Liu, Rongchen
AU  - Liu R
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Yan, Fangying
AU  - Yan F
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Chen, Yufei
AU  - Chen Y
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Gao, Xiufang
AU  - Gao X
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
FAU - Shi, Haiming
AU  - Shi H
AD  - Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200036, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190927
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6812474
OTO - NOTNLM
OT  - endothelial cells
OT  - monocyte adhesion
OT  - salidroside
OT  - tumor necrosis factor-alpha
OT  - vascular inflammation
EDAT- 2019/10/28 06:00
MHDA- 2019/10/28 06:01
PMCR- 2019/09/27
CRDT- 2019/10/29 06:00
PHST- 2019/03/07 00:00 [received]
PHST- 2019/09/10 00:00 [accepted]
PHST- 2019/10/29 06:00 [entrez]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2019/10/28 06:01 [medline]
PHST- 2019/09/27 00:00 [pmc-release]
AID - ETM-0-0-8064 [pii]
AID - 10.3892/etm.2019.8064 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Nov;18(5):4137-4143. doi: 10.3892/etm.2019.8064. Epub 2019 Sep 
      27.