PMID- 31657339
OWN - NLM
STAT- MEDLINE
DCOM- 20191029
LR  - 20200108
IS  - 2095-4352 (Print)
VI  - 31
IP  - 9
DP  - 2019 Sep
TI  - [Expressions of CD4(+)CD45RA(+)T cells and CD4(+)CD45RO(+)T cells in peripheral 
      blood of patients with acute coronary syndrome and their significance].
PG  - 1133-1136
LID - 10.3760/cma.j.issn.2095-4352.2019.09.015 [doi]
AB  - OBJECTIVE: To investigate the expressions of CD4(+)CD45RA(+)T cells and 
      CD4(+)CD45RO(+)T cells in peripheral blood of patients with acute coronary 
      syndrome (ACS) and their significance. METHODS: A case-control study was 
      conducted. Ninety-four patients receiving coronary angiography (CAG) admitted to 
      Tianjin Chest Hospital from March 5th to April 27th in 2018 were enrolled. They 
      were divided into non-coronary heart disease (CHD) group (n = 12), unstable 
      angina pectoris (UAP) group (n = 27), acute non-ST elevation myocardial 
      infarction (NSTEMI) group (n = 27) and acute ST elevation myocardial infarction 
      (STEMI) group (n = 28) according to the patients' symptoms, electrocardiogram, 
      troponin test and angiographic results. General data, blood routine parameters, 
      and biochemical indicators were collected. The ratios of CD4(+)CD45RA(+)T cells 
      and CD4(+)CD45RO(+)T cells were determined by flow cytometry. Multivariate 
      Logistic regression was used to evaluate whether CD4(+)CD45RA(+)T cells and 
      CD4(+)CD45RO(+)T cells were associated with STEMI. RESULTS: Ninety-four patients 
      were included initially. After excluding the patients who died during the 
      intervention, 93 patients were enrolled in the data analysis finally, with 12 
      patients in the non-CHD group, 27 patients in the UAP group, and the same as the 
      NSTEMI group and the STEMI group. Compared with the non-CHD group, white blood 
      cell count (WBC) was decreased (x10(9)/L: 6.03+/-1.30 vs. 6.60+/-1.30, P < 0.05), and 
      lymphocyte ratio was increased (0.273+/-0.059 vs. 0.269+/-0.070, P > 0.05) in 
      patients of the UAP group; however, in the NSTEMI group and STEMI group, WBC was 
      increased (x10(9)/L: 8.29+/-2.28, 9.86+/-2.76 vs. 6.60+/-1.30, both P < 0.05), and 
      lymphocyte ratio was decreased (0.236+/-0.076, 0.173+/-0.094 vs. 0.269+/-0.070, P > 
      0.05 and P < 0.05), especially in the STEMI group [WBC (x10(9)/L): 9.86+/-2.76 vs. 
      6.60+/-1.30, lymphocyte ratio: 0.173+/-0.094 vs. 0.269+/-0.070, both P < 0.05]. There 
      was no significant difference in biochemical indicators among all of the groups. 
      Flow cytometry results showed that the ratios of CD4(+)CD45RO(+)T cells in the 
      UAP group and NSTEMI group were higher than those in the non-CHD group 
      (0.323+/-0.074, 0.319+/-0.078 vs. 0.314+/-0.058, both P > 0.05); however, the ratio of 
      CD4(+)CD45RO(+)T cells in the STEMI group showed a decreased tendency 
      (0.270+/-0.057 vs. 0.314+/-0.058, P > 0.05), and it was significantly lower than that 
      in the UAP group and the NSTEMI group (0.270+/-0.057 vs. 0.323+/-0.074, 0.319+/-0.078, 
      both P < 0.05). There was no significant difference in the ratio of 
      CD4(+)CD45RA(+)T cells among all of the groups. Multivariate Logistic regression 
      analysis showed that CD4(+)CD45RA(+)T cells ratio was not significantly 
      correlated with the occurrence of STEMI [odds ratio (OR) = 0.976, 95% confidence 
      interval (95%CI) was 0.907-1.050, P = 0.518], but CD4(+)CD45RO(+)T cells ratio 
      was significantly correlated with the occurrence of STEMI (OR = 0.888, 95%CI was 
      0.821-0.961, P = 0.003). CONCLUSIONS: There was no significant difference in the 
      ratio of CD4(+)CD45RA(+)T cells among UAP, NSTEMI and STEMI patients, and 
      CD4(+)CD45RO(+)T cells ratio in the STEMI group was significantly lower than that 
      in the UAP group and NSTEMI group. CD4(+)CD45RO(+)T cells ratio may be risk 
      factor of STEMI.
FAU - Ma, Yue
AU  - Ma Y
AD  - Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China. 
      Corresponding author: Zhang Jingxia, Email: zhangjingxia001@126.com.
FAU - Zhang, Yingyi
AU  - Zhang Y
FAU - Zhang, Jingxia
AU  - Zhang J
FAU - Cong, Hongliang
AU  - Cong H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
SB  - IM
MH  - *Acute Coronary Syndrome
MH  - Angina, Unstable
MH  - Case-Control Studies
MH  - Humans
MH  - *Myocardial Infarction
MH  - T-Lymphocytes
EDAT- 2019/10/28 06:00
MHDA- 2019/10/30 06:00
CRDT- 2019/10/29 06:00
PHST- 2019/10/29 06:00 [entrez]
PHST- 2019/10/28 06:00 [pubmed]
PHST- 2019/10/30 06:00 [medline]
AID - 10.3760/cma.j.issn.2095-4352.2019.09.015 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Sep;31(9):1133-1136. doi: 
      10.3760/cma.j.issn.2095-4352.2019.09.015.