PMID- 31658247
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20210110
IS  - 1553-7358 (Electronic)
IS  - 1553-734X (Print)
IS  - 1553-734X (Linking)
VI  - 15
IP  - 10
DP  - 2019 Oct
TI  - Scar shape analysis and simulated electrical instabilities in a non-ischemic 
      dilated cardiomyopathy patient cohort.
PG  - e1007421
LID - 10.1371/journal.pcbi.1007421 [doi]
LID - e1007421
AB  - This paper presents a morphological analysis of fibrotic scarring in non-ischemic 
      dilated cardiomyopathy, and its relationship to electrical instabilities which 
      underlie reentrant arrhythmias. Two dimensional electrophysiological simulation 
      models were constructed from a set of 699 late gadolinium enhanced cardiac 
      magnetic resonance images originating from 157 patients. Areas of late gadolinium 
      enhancement (LGE) in each image were assigned one of 10 possible microstructures, 
      which modelled the details of fibrotic scarring an order of magnitude below the 
      MRI scan resolution. A simulated programmed electrical stimulation protocol 
      tested each model for the possibility of generating either a transmural block or 
      a transmural reentry. The outcomes of the simulations were compared against 
      morphological LGE features extracted from the images. Models which blocked or 
      reentered, grouped by microstructure, were significantly different from one 
      another in myocardial-LGE interface length, number of components and entropy, but 
      not in relative area and transmurality. With an unknown microstructure, 
      transmurality alone was the best predictor of block, whereas a combination of 
      interface length, transmurality and number of components was the best predictor 
      of reentry in linear discriminant analysis.
FAU - Balaban, Gabriel
AU  - Balaban G
AUID- ORCID: 0000-0002-6794-9611
AD  - Department of Informatics, University of Oslo, Oslo, Norway.
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, United Kingdom.
FAU - Halliday, Brian P
AU  - Halliday BP
AUID- ORCID: 0000-0002-5876-1748
AD  - National Heart and Lung Institute, Imperial College, London, United Kingdom.
FAU - Bai, Wenjia
AU  - Bai W
AD  - Department of Computing, Imperial College, London, United Kingdom.
FAU - Porter, Bradley
AU  - Porter B
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, United Kingdom.
FAU - Malvuccio, Carlotta
AU  - Malvuccio C
AD  - Department of Informatics, King's College London, London, United Kingdom.
FAU - Lamata, Pablo
AU  - Lamata P
AUID- ORCID: 0000-0002-3097-4928
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, United Kingdom.
FAU - Rinaldi, Christopher A
AU  - Rinaldi CA
AD  - Department of Cardiology, Guy's and St. Thomas Hospital Trust, London, United 
      Kingdom.
FAU - Plank, Gernot
AU  - Plank G
AD  - Institute of Biophysics, Medical University of Graz, Graz, Austria.
FAU - Rueckert, Daniel
AU  - Rueckert D
AUID- ORCID: 0000-0002-5683-5889
AD  - Department of Computing, Imperial College, London, United Kingdom.
FAU - Prasad, Sanjay K
AU  - Prasad SK
AD  - National Heart and Lung Institute, Imperial College, London, United Kingdom.
AD  - Cardiovascular Research Centre and Cardiovascular Magnetic Resonance Unit, Royal 
      Brompton Hospital, London, United Kingdom.
FAU - Bishop, Martin J
AU  - Bishop MJ
AUID- ORCID: 0000-0002-6237-1902
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, United Kingdom.
LA  - eng
GR  - MR/ N011007/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/N011007/1/MRC_/Medical Research Council/United Kingdom
GR  - WT 088641/Z/09/Z/WT_/Wellcome Trust/United Kingdom
GR  - PG/14/66/30927/BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
GR  - 209450/Z/17/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191028
PL  - United States
TA  - PLoS Comput Biol
JT  - PLoS computational biology
JID - 101238922
SB  - IM
MH  - Arrhythmias, Cardiac/etiology/*pathology
MH  - Cardiomyopathy, Dilated/*physiopathology
MH  - Cicatrix/*pathology
MH  - Cohort Studies
MH  - Computer Simulation
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Linear Models
MH  - Magnetic Resonance Imaging/methods
MH  - Models, Theoretical
MH  - Myocardial Infarction/pathology
MH  - Myocardial Ischemia/pathology
MH  - Myocardium/pathology
PMC - PMC6837623
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/10/29 06:00
MHDA- 2020/02/06 06:00
PMCR- 2019/10/28
CRDT- 2019/10/29 06:00
PHST- 2019/05/18 00:00 [received]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2019/11/07 00:00 [revised]
PHST- 2019/10/29 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/10/29 06:00 [entrez]
PHST- 2019/10/28 00:00 [pmc-release]
AID - PCOMPBIOL-D-19-00760 [pii]
AID - 10.1371/journal.pcbi.1007421 [doi]
PST - epublish
SO  - PLoS Comput Biol. 2019 Oct 28;15(10):e1007421. doi: 10.1371/journal.pcbi.1007421. 
      eCollection 2019 Oct.