PMID- 31659017
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 203
IP  - 11
DP  - 2019 Dec 1
TI  - Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of 
      Intestinal Tissue Homeostasis.
PG  - 3068-3077
LID - 10.4049/jimmunol.1900320 [doi]
AB  - Dendritic cells (DCs) together with regulatory T cells (Tregs) are essential 
      mediators of immune homeostasis. Disruption of function or frequency of either 
      cell type can lead to fatal autoimmunity. We previously described that mice 
      constitutively lacking DCs (∆DC) develop autoimmunity characterized by reduced 
      body weight, autoantibodies, and pronounced intestinal inflammation. In this 
      study, we show that lack of DCs leads to an altered gene expression profile in 
      peripheral but not thymic Tregs with increased expression of inhibitory 
      receptors. The suppressive function of Tregs from DeltaDC mice was impaired in T cell 
      cocultures. In a model of transfer colitis, Tregs from ∆DC mice were only 
      functional in the presence of DCs in recipient mice. Lack of MHC class II on DCs 
      also resulted in upregulation of inhibitory receptors on Tregs, reduced body 
      weight, and elevated serum IgA levels. Further analysis of the IgA response 
      revealed an expansion of IgA(+) germinal center B cells and plasma cells in 
      mesenteric lymph nodes and more IgA-coated commensal bacteria in feces of ∆DC 
      mice. Thus, we show a critical role for DCs to establish intestinal homeostasis 
      by regulating Treg function for prevention of spontaneous inflammation.
CI  - Copyright (c) 2019 by The American Association of Immunologists, Inc.
FAU - Hilpert, Cornelia
AU  - Hilpert C
AUID- ORCID: 0000-0002-8761-9206
AD  - Department of Infection Biology, University Hospital Erlangen and 
      Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
FAU - Sitte, Selina
AU  - Sitte S
AD  - Department of Infection Biology, University Hospital Erlangen and 
      Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
FAU - Arnold, Harald
AU  - Arnold H
AD  - Institute for Clinical Microbiology, Immunology and Hygiene, University Hospital 
      Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, 
      Germany; and.
FAU - Lehmann, Christian H K
AU  - Lehmann CHK
AUID- ORCID: 0000-0001-5927-9761
AD  - Department of Dermatology, Laboratory of Dendritic Cell Biology, University 
      Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 
      Erlangen, Germany.
FAU - Dudziak, Diana
AU  - Dudziak D
AUID- ORCID: 0000-0001-9358-134X
AD  - Department of Dermatology, Laboratory of Dendritic Cell Biology, University 
      Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 
      Erlangen, Germany.
FAU - Mattner, Jochen
AU  - Mattner J
AUID- ORCID: 0000-0003-2254-6664
AD  - Institute for Clinical Microbiology, Immunology and Hygiene, University Hospital 
      Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, 
      Germany; and.
FAU - Voehringer, David
AU  - Voehringer D
AUID- ORCID: 0000-0001-6650-0639
AD  - Department of Infection Biology, University Hospital Erlangen and 
      Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany; 
      david.voehringer@uk-erlangen.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191028
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Homeostasis/*immunology
MH  - Intestines/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2019/10/30 06:00
MHDA- 2020/05/28 06:00
CRDT- 2019/10/30 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/09/25 00:00 [accepted]
PHST- 2019/10/30 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/10/30 06:00 [entrez]
AID - jimmunol.1900320 [pii]
AID - 10.4049/jimmunol.1900320 [doi]
PST - ppublish
SO  - J Immunol. 2019 Dec 1;203(11):3068-3077. doi: 10.4049/jimmunol.1900320. Epub 2019 
      Oct 28.