PMID- 31659945
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20210609
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 20
IP  - 4
DP  - 2020
TI  - Immunogenetics of Celiac Disease: A Focus on Arab Countries.
PG  - 275-285
LID - 10.2174/1566524019666191024104930 [doi]
AB  - Celiac Disease (CD) is a complex immunogenic disease mainly triggered by gluten 
      intake in genetically susceptible individuals with a prevalence of 1 in 100-300. 
      CD results from the interplay between genetic and environmental factors. Genetic 
      susceptibility is believed to play a prominent role in the pathogenicity of CD, 
      mainly due to human leukocyte antigen (HLA)-related class II genes. Although CD 
      is wellrecognized among Arab populations, there are few studies on the genetic 
      epidemiology and prevalence of CD in the Arab countries. Therefore, the aim of 
      this review was to highlight the importance of studying this disease in the Arab 
      world in the context of a global perspective. Within the few studies published so 
      far, it was found that Arab populations have a distinctive susceptibility genetic 
      profile from other ethnic groups with the DQ2.5 and DQ8 genotypes that are 
      considered the major genotypes that confer susceptibility among Arab patients 
      with CD. Our findings will pave the way to perform further epidemiological 
      studies that will help identify potential therapeutic targets against CD among 
      Arab patients that are diagnosed with CD.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Younes, Nadin
AU  - Younes N
AD  - College of Health Sciences, Biomedical Sciences Department, Qatar University, 
      Doha, Qatar.
FAU - Younes, Salma
AU  - Younes S
AD  - College of Health Sciences, Biomedical Sciences Department, Qatar University, 
      Doha, Qatar.
FAU - Alsharabasi, Ola A
AU  - Alsharabasi OA
AD  - College of Health Sciences, Biomedical Sciences Department, Qatar University, 
      Doha, Qatar.
FAU - El Zowalaty, Mohamed E
AU  - El Zowalaty ME
AD  - Virology and Microbiology Research Group, College of Pharmacy, City University 
      College of Ajman, Ajman, United Arab Emirates.
FAU - Mustafa, Ibrahim
AU  - Mustafa I
AD  - College of Health Sciences, Biomedical Sciences Department, Qatar University, 
      Doha, Qatar.
FAU - Jahromi, Mohamed
AU  - Jahromi M
AD  - Clinical Research, Clinical Services Division, Dasman Diabetes Institute, Kuwait.
FAU - Uddin, Shahab
AU  - Uddin S
AD  - Department of Allergy and Immunology, Hamad Medical Corporation, Doha, Qatar.
FAU - Al-Nesf, Mariam
AU  - Al-Nesf M
AD  - Academic health system, Translational research institute, Hamad Medical 
      Corporation, Doha, Qatar.
FAU - Pintus, Gianfranco
AU  - Pintus G
AD  - Department of Medical Laboratory Sciences, University of Sharjah, 27272 2 
      Sharjah, United Arab Emirates.
FAU - Zayed, Hatem
AU  - Zayed H
AD  - College of Health Sciences, Biomedical Sciences Department, Qatar University, 
      Doha, Qatar.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Celiac Disease/diagnosis/epidemiology/*genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/immunology
MH  - Humans
MH  - *Immunogenetics
MH  - Middle East/epidemiology
MH  - Prevalence
OTO - NOTNLM
OT  - Arab countries
OT  - Celiac disease
OT  - HLA
OT  - genetic susceptibility
OT  - gluten
OT  - incidence
OT  - prevalence.
EDAT- 2019/10/30 06:00
MHDA- 2021/06/10 06:00
CRDT- 2019/10/30 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2019/10/08 00:00 [revised]
PHST- 2019/10/16 00:00 [accepted]
PHST- 2019/10/30 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2019/10/30 06:00 [entrez]
AID - CMM-EPUB-101851 [pii]
AID - 10.2174/1566524019666191024104930 [doi]
PST - ppublish
SO  - Curr Mol Med. 2020;20(4):275-285. doi: 10.2174/1566524019666191024104930.