PMID- 31661339
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 61
IP  - 3
DP  - 2020 Mar
TI  - Early induction intensification with cladribine, cytarabine, and mitoxantrone 
      (CLAM) in AML patients treated with the DAC induction regimen: a prospective, 
      non-randomized, phase II study of the Polish Adult Leukemia Group (PALG).
PG  - 588-603
LID - 10.1080/10428194.2019.1678151 [doi]
AB  - We present the results of a prospective, non-randomized phase 2 trial in which 
      253 AML patients (pts) under 60 years old received DAC 
      (Daunorubicin + AraC + Cladribine) as first induction followed by CLAM 
      (Cladribine + AraC + Mitoxantrone) as early second induction on day 16 based on 
      bone marrow (BM) blasts on day 14 (D14). The CR/CRi rate after a single course of 
      DAC was 83% for pts with D14 BM blasts less than 10%. Forty-six pts had >10% BM 
      blasts on D14, of whom 35 received CLAM with rates of CR/CRi 60% and early death 
      (ED) 23%. The remaining 11 pts were not fit to receive CLAM, with rates of CR/CRi 
      28%, PR 18%, and ED 18%. Median OS was 7.2 versus 7.5 months, respectively. The 
      overall CR/CRi rate was 77% after the first induction, with final CR/CRi rate 80% 
      after DAC reinduction for pts who achieved PR with initial DAC course. CLAM used 
      as early second induction might improve CR/CRi rates for younger AML pts with 
      poor early response to DAC induction, but may be associated with higher 
      mortality.
FAU - Pluta, Agnieszka
AU  - Pluta A
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Robak, Tadeusz
AU  - Robak T
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Brzozowski, Kamil
AU  - Brzozowski K
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Stepka, Konrad
AU  - Stepka K
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Wawrzyniak, Ewa
AU  - Wawrzyniak E
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Krawczynska, Anna
AU  - Krawczynska A
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Czemerska, Magdalena
AU  - Czemerska M
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Szmigielska-Kaplon, Anna
AU  - Szmigielska-Kaplon A
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Grzybowska-Izydorczyk, Olga
AU  - Grzybowska-Izydorczyk O
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Nowicki, Mateusz
AU  - Nowicki M
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Stelmach, Piotr
AU  - Stelmach P
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Kuydowicz, Marta
AU  - Kuydowicz M
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
FAU - Gromek, Tomasz
AU  - Gromek T
AD  - Department of Hematooncology and Bone Marrow Transplantation, Medical University 
      of Lublin, Lublin, Poland.
FAU - Hus, Marek
AU  - Hus M
AD  - Department of Hematooncology and Bone Marrow Transplantation, Medical University 
      of Lublin, Lublin, Poland.
FAU - Helbig, Grzegorz
AU  - Helbig G
AD  - Department of Hematology and BMT, Medical School of Silesia, Katowice, Poland.
FAU - Grosicki, Sebastian
AU  - Grosicki S
AD  - Department of Cancer Prevention, School of Public Health, Medical University of 
      Silesia, Katowice, Poland.
FAU - Bodzenta, Ewa
AU  - Bodzenta E
AD  - Department of Hematology, Municipal Hospital, Chorzow, Poland.
FAU - Razny, Malgorzata
AU  - Razny M
AD  - Hematology Department, Rydygier Memorial Hospital, Krakow, Poland.
FAU - Wojcik, Karol
AU  - Wojcik K
AD  - Hematology Department, Rydygier Memorial Hospital, Krakow, Poland.
FAU - Bolkun, Lukasz
AU  - Bolkun L
AD  - Department of Hematology, Medical University Hospital, Bialystok, Poland.
FAU - Kloczko, Janusz
AU  - Kloczko J
AD  - Department of Hematology, Medical University Hospital, Bialystok, Poland.
FAU - Knopinska-Posluszny, Wanda
AU  - Knopinska-Posluszny W
AD  - Hematology Department, Hospital MSWiA, Olsztyn, Poland.
FAU - Piekarska, Agnieszka
AU  - Piekarska A
AD  - Department of Hematology, Transplantation Medical University of Gdansk, Gdansk, 
      Poland.
FAU - Hellman, Andrzej
AU  - Hellman A
AD  - Department of Hematology, Transplantation Medical University of Gdansk, Gdansk, 
      Poland.
FAU - Sobas, Marta
AU  - Sobas M
AUID- ORCID: 0000-0003-0781-8668
AD  - Department of Hematology, Blood Neoplasm and Bone Marrow Transplantation, 
      Wroclaw, Poland.
FAU - Wrobel, Tomasz
AU  - Wrobel T
AD  - Department of Hematology, Blood Neoplasm and Bone Marrow Transplantation, 
      Wroclaw, Poland.
FAU - Patkowska, Elzbieta
AU  - Patkowska E
AD  - Department of Hematology, Institute of Hematology and Transfusion Medicine, 
      Warsaw, Poland.
AD  - Department of Hematology and Transfusion Medicine, Centre of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Lech-Maranda, Ewa
AU  - Lech-Maranda E
AD  - Department of Hematology, Institute of Hematology and Transfusion Medicine, 
      Warsaw, Poland.
AD  - Department of Hematology and Transfusion Medicine, Centre of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Warzocha, Krzysztof
AU  - Warzocha K
AD  - Department of Hematology, Institute of Hematology and Transfusion Medicine, 
      Warsaw, Poland.
FAU - Holowiecki, Jerzy
AU  - Holowiecki J
AD  - Department of Bone Marrow Transplantation and Onco-Hematology, Maria 
      Sklodowska-Curie Institute - Cancer Center, Gliwice Branch, Gliwice, Poland.
FAU - Giebel, Sebastian
AU  - Giebel S
AD  - Department of Bone Marrow Transplantation and Onco-Hematology, Maria 
      Sklodowska-Curie Institute - Cancer Center, Gliwice Branch, Gliwice, Poland.
FAU - Wierzbowska, Agnieszka
AU  - Wierzbowska A
AD  - Department of Hematology, Medical University of Lodz, Lodz, Poland.
LA  - eng
SI  - ClinicalTrials.gov/NCT02072811
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191029
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 04079A1RDZ (Cytarabine)
RN  - 47M74X9YT5 (Cladribine)
RN  - BZ114NVM5P (Mitoxantrone)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects
MH  - *Cladribine/therapeutic use
MH  - Cytarabine/therapeutic use
MH  - Humans
MH  - *Leukemia, Myeloid, Acute/drug therapy
MH  - Middle Aged
MH  - Mitoxantrone/therapeutic use
MH  - Poland
MH  - Prospective Studies
MH  - Remission Induction
OTO - NOTNLM
OT  - AML
OT  - CLAM
OT  - early second induction
EDAT- 2019/10/30 06:00
MHDA- 2021/04/29 06:00
CRDT- 2019/10/30 06:00
PHST- 2019/10/30 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2019/10/30 06:00 [entrez]
AID - 10.1080/10428194.2019.1678151 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2020 Mar;61(3):588-603. doi: 10.1080/10428194.2019.1678151. Epub 
      2019 Oct 29.