PMID- 31662495
OWN - NLM
STAT- MEDLINE
DCOM- 20200319
LR  - 20211204
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 33
IP  - 6
DP  - 2019 Nov-Dec
TI  - Understanding the Role of ztor in Aging-related Diseases Using the Zebrafish 
      Model.
PG  - 1713-1720
LID - 10.21873/invivo.11661 [doi]
AB  - The mammalian target of rapamycin (mTOR), a 289 kDa serine/threonine protein 
      kinase of the phosphoinositide 3-kinase (PI3K)-related family is known for its 
      role in regulating lifespan and the aging process in humans and rodents. Aging in 
      zebrafish very much resembles aging in humans. Aged zebrafish often manifest with 
      spinal curvature, cataracts and cognitive frailty, akin to human age-related 
      phenotypical effects such as osteoarthritis, dwindling vision and cognitive 
      dysfunction. However, the role of the zebrafish orthologue of mTOR, ztor, is less 
      defined in these areas. This review paper discusses the tale of growing old in 
      the zebrafish, the physiological roles of ztor in normal developmental processes 
      and its involvement in the pathogenesis of aging-related diseases such as 
      metabolic disorders and cancers.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Khor, Eng-Soon
AU  - Khor ES
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Noor, Suzita Mohd
AU  - Noor SM
AD  - Department of Biomedical Science, Faculty of Medicine, University of Malaya, 
      Kuala Lumpur, Malaysia.
FAU - Wong, Pooi-Fong
AU  - Wong PF
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala 
      Lumpur, Malaysia wongpf@um.edu.my.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Humans
MH  - Neoplasms/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Zebrafish/*metabolism
PMC - PMC6899122
OTO - NOTNLM
OT  - Aging-related diseases
OT  - developmental
OT  - mTOR
OT  - review
OT  - zebrafish
OT  - ztor
COIS- The Authors declare no conflict of interest regarding this study.
EDAT- 2019/10/31 06:00
MHDA- 2020/03/20 06:00
PMCR- 2019/11/03
CRDT- 2019/10/31 06:00
PHST- 2019/08/06 00:00 [received]
PHST- 2019/08/15 00:00 [revised]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2020/03/20 06:00 [medline]
PHST- 2019/11/03 00:00 [pmc-release]
AID - 33/6/1713 [pii]
AID - 10.21873/invivo.11661 [doi]
PST - ppublish
SO  - In Vivo. 2019 Nov-Dec;33(6):1713-1720. doi: 10.21873/invivo.11661.