PMID- 31662553
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20200313
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 33
IP  - 6
DP  - 2019 Nov-Dec
TI  - Comparison of Material-mediated Bone Regeneration Capacities of Sintered and 
      Non-sintered Xenogeneic Bone Substitutes via 2D and 3D Data.
PG  - 2169-2179
LID - 10.21873/invivo.11719 [doi]
AB  - BACKGROUND/AIM: The aim of this study was the development of a new 
      osteoconductivity index to determine the bone healing capacities of bone 
      substitute materials (BSM) on the basis of 3D microcomputed tomographic (mu-CT) 
      data. MATERIALS AND METHODS: Sinus biopsies were used for the comparative 
      analysis of the integration behavior of two xenogeneic BSM (cerabone(R) and 
      Bio-Oss(R)). 3D mu-CT and data sets from histomorphometrical measurements based on 
      2D histological slices were used to measure the bone-material-contact and the 
      tissue distribution within the biopsies. The tissue reactions to both BSM were 
      microscopically analyzed. RESULTS: The 3D and 2D results of the osteoconductivity 
      measurements showed comparable material-bone contacts for both BSM, but the 2D 
      data were significantly lower. The same results were found when tissue 
      distribution was measured in both groups. The histopathological analysis showed 
      comparative tissue reactions in both BSM. CONCLUSION: Osteoconductivity index is 
      a reliable measurement parameter for determining the healing capacities of BSM. 
      The observed differences between both measurement methods could be assigned to 
      the resolution capacity of mu-CT data that did not allow for a precise interface 
      distinction between both BSM and bone tissue. Histomorphometrical data based on 
      histological slides still allow for a more exact evaluation.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Kapogianni, Eleni
AU  - Kapogianni E
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Barbeck, Mike
AU  - Barbeck M
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany mike.barbeck@icloud.com.
AD  - BerlinAnalytix GmbH, Berlin, Germany.
FAU - Jung, Ole
AU  - Jung O
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany.
AD  - BerlinAnalytix GmbH, Berlin, Germany.
FAU - Arslan, Aylin
AU  - Arslan A
AD  - BerlinAnalytix GmbH, Berlin, Germany.
FAU - Kuhnel, Lennart
AU  - Kuhnel L
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Xiong, Xin
AU  - Xiong X
AD  - Natural and Medical Sciences Institute, University of Tubingen, Reutlingen, 
      Germany.
FAU - Krastev, Rumen
AU  - Krastev R
AD  - Natural and Medical Sciences Institute, University of Tubingen, Reutlingen, 
      Germany.
AD  - Department of Intelligent Surfaces, Faculty of Applied Chemistry, Reutlingen 
      University, Reutlingen, Germany.
FAU - Friedrich, Reinhard E
AU  - Friedrich RE
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Schnettler, Reinhard
AU  - Schnettler R
AD  - Department of Oral and Maxillofacial Surgery, University Hospital 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Fienitz, Tim
AU  - Fienitz T
AD  - Department of Oral and Maxillofacial Plastic Surgery, Evangelic Johanniter 
      Hospital Bethesda Monchengladbach, Monchengladbach, Germany.
FAU - Rothamel, Daniel
AU  - Rothamel D
AD  - Department of Oral and Maxillofacial Plastic Surgery, Evangelic Johanniter 
      Hospital Bethesda Monchengladbach, Monchengladbach, Germany.
AD  - Department of Oral and Maxillofacial Plastic Surgery, Heinrich-Heine Universitat 
      Dusseldorf, Dusseldorf, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Bio-Oss)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Hydroxyapatites)
RN  - 0 (Minerals)
RN  - 0 (cerabone)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials
MH  - *Bone Regeneration
MH  - *Bone Substitutes
MH  - Bone and Bones
MH  - Cattle
MH  - Hydroxyapatites
MH  - Minerals
MH  - *X-Ray Microtomography
PMC - PMC6899141
OTO - NOTNLM
OT  - Osteoconductivity index
OT  - bone regeneration
OT  - histomorphometry
OT  - micro-CT
OT  - tissue response
OT  - xenogeneic bone substitute
COIS- The Authors declare no conflicts of interest regarding this study.
EDAT- 2019/10/31 06:00
MHDA- 2020/03/14 06:00
PMCR- 2019/11/03
CRDT- 2019/10/31 06:00
PHST- 2019/08/08 00:00 [received]
PHST- 2019/09/15 00:00 [revised]
PHST- 2019/09/16 00:00 [accepted]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
PHST- 2019/11/03 00:00 [pmc-release]
AID - 33/6/2169 [pii]
AID - 10.21873/invivo.11719 [doi]
PST - ppublish
SO  - In Vivo. 2019 Nov-Dec;33(6):2169-2179. doi: 10.21873/invivo.11719.