PMID- 31663023
OWN - NLM
STAT- MEDLINE
DCOM- 20200521
LR  - 20240421
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 5
IP  - 10
DP  - 2019 Oct
TI  - Mindfulness-Oriented Recovery Enhancement remediates hedonic dysregulation in 
      opioid users: Neural and affective evidence of target engagement.
PG  - eaax1569
LID - 10.1126/sciadv.aax1569 [doi]
LID - eaax1569
AB  - Addiction neuroscience models posit that recurrent drug use increases reactivity 
      to drug-related cues and blunts responsiveness to natural rewards, propelling a 
      cycle of hedonic dysregulation that drives addictive behavior. Here, we assessed 
      whether a cognitive intervention for addiction, Mindfulness-Oriented Recovery 
      Enhancement (MORE), could restructure reward responsiveness from valuation of 
      drug-related reward back to valuation of natural reward. Before and after 8 weeks 
      of MORE or a support group control, prescription opioid users (N = 135) viewed 
      opioid and natural reward cues while an electroencephalogram biomarker of target 
      engagement was assessed. MORE was associated with decreased opioid cue-reactivity 
      and enhanced capacity to regulate responses to opioid and natural reward cues. 
      Increased positive affective responses to natural reward cues were associated 
      with decreased craving and mediated MORE's therapeutic effects on opioid misuse. 
      This series of randomized experiments provide the first neurophysiological 
      evidence that an integrative behavioral treatment can remediate hedonic 
      dysregulation among chronic opioid users.
CI  - Copyright (c) 2019 The Authors, some rights reserved; exclusive licensee American 
      Association for the Advancement of Science. No claim to original U.S. Government 
      Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 
      (CC BY-NC).
FAU - Garland, Eric L
AU  - Garland EL
AUID- ORCID: 0000-0003-2891-857X
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA.
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA.
FAU - Atchley, Rachel M
AU  - Atchley RM
AUID- ORCID: 0000-0003-2610-5081
AD  - Department of Anesthesiology, Harvard University, Boston, MA, USA.
FAU - Hanley, Adam W
AU  - Hanley AW
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA.
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA.
FAU - Zubieta, Jon-Kar
AU  - Zubieta JK
AUID- ORCID: 0000-0002-1758-9339
AD  - Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
FAU - Froeliger, Brett
AU  - Froeliger B
AUID- ORCID: 0000-0001-9451-9900
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 
      USA.
LA  - eng
GR  - R01 DA042033/DA/NIDA NIH HHS/United States
GR  - R61 AT009296/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20191016
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/therapeutic use
MH  - Chronic Pain/drug therapy/psychology
MH  - Cues
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mindfulness
MH  - Opioid-Related Disorders/*psychology
MH  - Reward
PMC - PMC6795512
EDAT- 2019/10/31 06:00
MHDA- 2020/05/22 06:00
PMCR- 2019/10/16
CRDT- 2019/10/31 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/09/25 00:00 [accepted]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2020/05/22 06:00 [medline]
PHST- 2019/10/16 00:00 [pmc-release]
AID - aax1569 [pii]
AID - 10.1126/sciadv.aax1569 [doi]
PST - epublish
SO  - Sci Adv. 2019 Oct 16;5(10):eaax1569. doi: 10.1126/sciadv.aax1569. eCollection 
      2019 Oct.