PMID- 31663252
OWN - NLM
STAT- MEDLINE
DCOM- 20210113
LR  - 20210113
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 19
IP  - 1
DP  - 2020 Jan
TI  - Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces 
      Abeta levels in Alzheimer's disease models.
PG  - e13054
LID - 10.1111/acel.13054 [doi]
LID - e13054
AB  - A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid-beta (Abeta), 
      which correlates significantly with progressive cognitive deficits. Although 
      photobiomodulation therapy (PBMT), as a novel noninvasive physiotherapy strategy, 
      has been proposed to improve neuronal survival, decrease neuron loss, ameliorate 
      dendritic atrophy, and provide overall AD improvement, it remains unknown whether 
      and how this neuroprotective process affects Abeta levels. Here, we report that PBMT 
      reduced Abeta production and plaque formation by shifting amyloid precursor protein 
      (APP) processing toward the nonamyloidogenic pathway, thereby improving memory 
      and cognitive ability in a mouse model of AD. More importantly, a pivotal 
      protein, SIRT1, was involved in this process by specifically up-regulating ADAM10 
      and down-regulating BACE1, which is dependent on the cAMP/PKA pathway in APP/PS1 
      primary neurons and SH-SY5Y cells stably expressing human APP Swedish mutation 
      (APPswe). We further found that the activity of the mitochondrial photoacceptor 
      cytochrome c oxidase (CcO) was responsible for PBMT-induced activation of PKA and 
      SIRT1. Together, our research suggests that PBMT as a viable therapeutic strategy 
      has great potential value in improving cognitive ability and combatting AD.
CI  - (c) 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Zhang, Zhan
AU  - Zhang Z
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South 
      China Normal University, Guangzhou, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou, China.
FAU - Shen, Qi
AU  - Shen Q
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South 
      China Normal University, Guangzhou, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou, China.
FAU - Wu, Xiaolei
AU  - Wu X
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South 
      China Normal University, Guangzhou, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou, China.
FAU - Zhang, Di
AU  - Zhang D
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South 
      China Normal University, Guangzhou, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou, China.
FAU - Xing, Da
AU  - Xing D
AUID- ORCID: 0000-0001-9752-8458
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South 
      China Normal University, Guangzhou, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou, China.
LA  - eng
GR  - 2014A030313419/Natural Science Foundation of Guangdong Province/International
GR  - 31470072/National Natural Science Foundation of China/International
GR  - 61361160414/National Natural Science Foundation of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191030
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Amyloid beta-Peptides)
RN  - EC 3.5.1.- (Sirt1 protein, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Alzheimer Disease/*genetics/therapy
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Low-Level Light Therapy/*methods
MH  - Mice
MH  - Mice, Transgenic
MH  - Sirtuin 1/isolation & purification/*metabolism
PMC - PMC6974721
OTO - NOTNLM
OT  - APP processing
OT  - Alzheimer's disease
OT  - SIRT1
OT  - amyloid-beta
OT  - cAMP/PKA pathway
OT  - photobiomodulation therapy
COIS- None declared.
EDAT- 2019/10/31 06:00
MHDA- 2021/01/14 06:00
PMCR- 2020/01/01
CRDT- 2019/10/31 06:00
PHST- 2019/06/03 00:00 [received]
PHST- 2019/09/13 00:00 [revised]
PHST- 2019/10/05 00:00 [accepted]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2021/01/14 06:00 [medline]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ACEL13054 [pii]
AID - 10.1111/acel.13054 [doi]
PST - ppublish
SO  - Aging Cell. 2020 Jan;19(1):e13054. doi: 10.1111/acel.13054. Epub 2019 Oct 30.