PMID- 31663297
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20221207
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 7
IP  - 12
DP  - 2019 Dec
TI  - Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) 
      susceptibility.
PG  - e1020
LID - 10.1002/mgg3.1020 [doi]
LID - e1020
AB  - INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is essential in 
      mediating folate metabolism, and thus plays an important role in diabetes and 
      diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been 
      proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. 
      However, the conclusions are inconsistent. Therefore, we rechecked their linkage 
      aiming to obtain a more reliable estimation by performing an updated 
      meta-analysis. METHODS: We searched electronic databases PubMed, EMBASE, CNKI, 
      and Wanfang to obtain studies updated to October 2019. RESULTS: After carefully 
      screening, we finally incorporated 68 studies with 10,812 cases and 8,745 
      controls. The genotype frequency of C677T polymorphism was analyzed pooled to 
      generate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled results 
      presented that MTHFR C677T polymorphism was significantly associated with T2DM 
      under homozygous (OR = 1.64, 95% CI = 1.39-1.94), heterozygous (OR = 1.38, 95% 
      CI = 1.20-1.59), recessive (OR = 1.41, 95% CI = 1.23-1.61), dominant (OR = 1.47, 
      95% CI = 1.27-1.70), and allele (OR = 1.37, 95% CI = 1.23-1.52) genetic models. 
      Stratified analysis demonstrated that C677T genotype was associated with T2DM in 
      Asian populations, but not Caucasian and African populations. CONCLUSION: Our 
      results indicated that MTHFR C677T polymorphism confers to T2DM, especially in 
      Asian populations. Much more large-scale case-control studies are needed to 
      strengthen such conclusion in the future.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Meng, Yanzi
AU  - Meng Y
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, Henan, China.
AD  - Jincheng General Hospital, Jincheng Coal General Hospital, Jincheng, Shannxi, 
      China.
FAU - Liu, Xiaoling
AU  - Liu X
AD  - Endocrinology Department, Affiliated Hospital of Guilin Medical University, 
      Guilin, Guangxi, China.
FAU - Ma, Kai
AU  - Ma K
AD  - Hematology Department, Jincheng People's Hospital, Jincheng, Shannxi, China.
FAU - Zhang, Lili
AU  - Zhang L
AD  - Endocrinology Department, Jincheng General Hospital, Jincheng Coal General 
      Hospital, Jincheng, Shannxi, China.
FAU - Lu, Mao
AU  - Lu M
AD  - Laboratory Medicine Department, Jincheng General Hospital, Jincheng Coal General 
      Hospital, Jincheng, Shannxi, China.
FAU - Zhao, Minsu
AU  - Zhao M
AD  - Endocrinology Department, Jincheng People's Hospital, Jincheng, Shannxi, China.
FAU - Guan, Min-Xin
AU  - Guan MX
AD  - Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Qin, Guijun
AU  - Qin G
AUID- ORCID: 0000-0002-0533-9981
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, Henan, China.
LA  - eng
SI  - GENBANK/NM_005957.5
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20191030
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Asian People/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
PMC - PMC6900375
OTO - NOTNLM
OT  - MTHFR
OT  - C677T
OT  - T2DM
OT  - meta-analysis
OT  - polymorphism
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/10/31 06:00
MHDA- 2020/06/20 06:00
PMCR- 2019/10/30
CRDT- 2019/10/31 06:00
PHST- 2019/06/21 00:00 [received]
PHST- 2019/10/06 00:00 [revised]
PHST- 2019/10/09 00:00 [accepted]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2019/10/30 00:00 [pmc-release]
AID - MGG31020 [pii]
AID - 10.1002/mgg3.1020 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2019 Dec;7(12):e1020. doi: 10.1002/mgg3.1020. Epub 2019 
      Oct 30.