PMID- 31664483 OWN - NLM STAT- MEDLINE DCOM- 20200326 LR - 20200326 IS - 1432-0614 (Electronic) IS - 0175-7598 (Linking) VI - 103 IP - 23-24 DP - 2019 Dec TI - Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus. PG - 9229-9238 LID - 10.1007/s00253-019-10156-y [doi] AB - The worldwide prevalence of type 2 diabetes mellitus (T2DM) is constantly increasing, and it has become a major concern, with several implications for public health, economy, and social well-being. It is well-known that several factors such as lifestyle, increased intake of fat and sugar-rich foods, and host genetics can lead to T2DM. Some recent studies have suggested that the composition of the intestinal microbiota can trigger T2DM. Since then, considerable effort has been made to understand the link between the composition of intestinal microbiota and T2DM, as well as the role of probiotics in modulation of intestinal microbiota. This mini-review summarizes the major findings and discusses the close relationship between intestinal microbiota, probiotics, and T2DM. FAU - Salgaco, Mateus Kawata AU - Salgaco MK AD - Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of Sao Paulo (UNESP), Araraquara, SP, Brazil. FAU - Oliveira, Liliane Garcia Segura AU - Oliveira LGS AD - Program of Master Degree Science and Technology of Milk and Dairy Products, University Pitagoras Unopar, Londrina, PR, Brazil. FAU - Costa, Giselle Nobre AU - Costa GN AD - Program of Master Degree Science and Technology of Milk and Dairy Products, University Pitagoras Unopar, Londrina, PR, Brazil. FAU - Bianchi, Fernanda AU - Bianchi F AD - Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of Sao Paulo (UNESP), Araraquara, SP, Brazil. FAU - Sivieri, Katia AU - Sivieri K AUID- ORCID: 0000-0001-8632-1478 AD - Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of Sao Paulo (UNESP), Araraquara, SP, Brazil. katia.sivieri@unesp.br. AD - Program of Master Degree Science and Technology of Milk and Dairy Products, University Pitagoras Unopar, Londrina, PR, Brazil. katia.sivieri@unesp.br. LA - eng PT - Journal Article PT - Review DEP - 20191029 PL - Germany TA - Appl Microbiol Biotechnol JT - Applied microbiology and biotechnology JID - 8406612 RN - 0 (Prebiotics) SB - IM MH - Diabetes Mellitus, Type 2/*microbiology/*prevention & control MH - *Gastrointestinal Microbiome MH - Humans MH - Prebiotics MH - *Probiotics OTO - NOTNLM OT - Chronic disease OT - Gut microbiota OT - Probiotic OT - Type 2 diabetes EDAT- 2019/10/31 06:00 MHDA- 2020/03/27 06:00 CRDT- 2019/10/31 06:00 PHST- 2019/07/26 00:00 [received] PHST- 2019/09/24 00:00 [accepted] PHST- 2019/09/20 00:00 [revised] PHST- 2019/10/31 06:00 [pubmed] PHST- 2020/03/27 06:00 [medline] PHST- 2019/10/31 06:00 [entrez] AID - 10.1007/s00253-019-10156-y [pii] AID - 10.1007/s00253-019-10156-y [doi] PST - ppublish SO - Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9229-9238. doi: 10.1007/s00253-019-10156-y. Epub 2019 Oct 29.