PMID- 31665070 OWN - NLM STAT- MEDLINE DCOM- 20200115 LR - 20200115 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 16 IP - 1 DP - 2019 Oct 29 TI - The effect of low dose marine protein hydrolysates on short-term recovery after high intensity performance cycling: a double-blinded crossover study. PG - 48 LID - 10.1186/s12970-019-0318-3 [doi] LID - 48 AB - BACKGROUND: Knowledge of the effect of marine protein hydrolysate (MPH) supplementation to promote recovery after high intensity performance training is scarce. The aim of this study was to examine the effect of MPH supplementation to whey protein (WP) and carbohydrate (CHO): (CHO-WP-MPH), on short-term recovery following high intensity performance, compared to an isoenergetic and isonitrogenous supplement of WP and CHO: (CHO-WP), in male cyclists. METHODS: This was a double-blinded crossover study divided into three phases. Fourteen healthy men participated. In phase I, an incremental bicycle exercise test was performed for establishment of intensities used in phase II and III. In phase II (9-16 days after phase 1), the participants performed first one high intensity performance cycling session, followed by nutrition supplementation (CHO-WP-MPH or CHO-WP) and 4 hours of recovery, before a subsequent high intensity performance cycling session. Phase III (1 week after phase II), was similar to phase II except for the nutrition supplementation, where the participants received the opposite supplementation compared to phase II. Primary outcome was difference in time to exhaustion between the cycling sessions, after nutrition supplementations containing MPH or without MPH. Secondary outcomes were differences in heart rate (HR), respiratory exchange ratio (RER), blood lactate concentration and glucose. RESULTS: The mean age of the participants was 45.6 years (range 40-58). The maximal oxygen uptake (mean +/- SD) measured at baseline was 54.7 +/- 4.1 ml∙min(- 1)∙kg(- 1). There were no significant differences between the two nutrition supplementations measured by time to exhaustion at the cycling sessions (mean(diff) = 0.85 min, p = 0.156, 95% confidence interval (CI), - 0.37, 2.06), HR (mean(diff) = 0.8 beats pr.min, p = 0.331, 95% CI, - 0.9, 2.5), RER (mean(diff) = - 0.05, p = 0.361, 95% CI -0.07 - 0.17), blood lactate concentration (mean(diff) = - 0.24, p = 0.511, 95% CI, - 1.00, 0.53) and glucose (mean(diff) = 0.23, p = 0.094, 95% CI, - 0.05, 0.51). CONCLUSIONS: A protein supplement with MPH showed no effects on short-term recovery in middle-aged healthy male cyclists compared to a protein supplement without MPH. TRIAL REGISTRATION: The study was registered 02.05.2017 at ClinicalTrials.gov (Protein Supplements to Cyclists, NCT03136133 , https://clinicaltrials.gov/ct2/show/NCT03136133?cond=marine+peptides&rank=1 . FAU - Mjos, Ingunn AU - Mjos I AD - Department of Health and Functioning, Western Norway University of Applied Sciences, Pb. 7030, 5020, Bergen, Norway. AD - Department of Physiotherapy, Haukeland University Hospital, Bergen, Norway. FAU - Thorsen, Einar AU - Thorsen E AD - Dept. of Clinical Science, University of Bergen, Bergen, Norway. AD - Dept. of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Hausken, Trygve AU - Hausken T AD - Dept. of Clinical Medicine, University of Bergen, Bergen, Norway. AD - National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway. FAU - Lied, Einar AU - Lied E AD - Firmenich Bjorge Biomarin A/S, Aalesund, Norway. FAU - Nilsen, Roy M AU - Nilsen RM AD - Department of Health and Functioning, Western Norway University of Applied Sciences, Pb. 7030, 5020, Bergen, Norway. FAU - Bronstad, Ingeborg AU - Bronstad I AD - Dept. of Clinical Medicine, University of Bergen, Bergen, Norway. AD - National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway. FAU - Edvardsen, Elisabeth AU - Edvardsen E AD - Dept. of Pulmonary Medicine, Oslo University Hospital, Ulleval, Oslo, Norway. AD - Norwegian School of Sport Sciences, Oslo, Norway. FAU - Frisk, Bente AU - Frisk B AD - Department of Health and Functioning, Western Norway University of Applied Sciences, Pb. 7030, 5020, Bergen, Norway. bente.frisk@hvl.no. AD - Department of Physiotherapy, Haukeland University Hospital, Bergen, Norway. bente.frisk@hvl.no. LA - eng SI - ClinicalTrials.gov/NCT03136133 PT - Journal Article PT - Randomized Controlled Trial DEP - 20191029 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 RN - 0 (Blood Glucose) RN - 0 (Dietary Carbohydrates) RN - 0 (Protein Hydrolysates) RN - 0 (Whey Proteins) RN - 33X04XA5AT (Lactic Acid) SB - IM EIN - J Int Soc Sports Nutr. 2020 Jan 3;17(1):1. PMID: 31898530 MH - Adult MH - Athletic Performance/*physiology MH - Bicycling/*physiology MH - Blood Glucose MH - Cross-Over Studies MH - Dietary Carbohydrates/administration & dosage MH - *Dietary Supplements MH - Double-Blind Method MH - Exercise Test MH - Heart Rate MH - Humans MH - Lactic Acid/blood MH - Male MH - Middle Aged MH - Protein Hydrolysates/*administration & dosage MH - Sports Nutritional Physiological Phenomena MH - Whey Proteins/administration & dosage PMC - PMC6819466 OTO - NOTNLM OT - Endurance exercise OT - Hydrolysed proteins OT - Marine protein hydrolysate OT - Recovery COIS- One of the co-authors, Einar Lied, was representing Firmenich Bjorge Biomarine A/S who was funding the study and responsible for composing the diets. To ensure that none of the authors were influenced if the diets contained marine protein hydrolysate or not, the study was double blinded, and the researchers who did the statistical analyses did not know anything about the order of the diets before all the analyses were completed and the results were given. The other authors have no competing interests. EDAT- 2019/10/31 06:00 MHDA- 2020/01/16 06:00 PMCR- 2019/10/29 CRDT- 2019/10/31 06:00 PHST- 2019/02/25 00:00 [received] PHST- 2019/10/10 00:00 [accepted] PHST- 2019/10/31 06:00 [entrez] PHST- 2019/10/31 06:00 [pubmed] PHST- 2020/01/16 06:00 [medline] PHST- 2019/10/29 00:00 [pmc-release] AID - 10.1186/s12970-019-0318-3 [pii] AID - 318 [pii] AID - 10.1186/s12970-019-0318-3 [doi] PST - epublish SO - J Int Soc Sports Nutr. 2019 Oct 29;16(1):48. doi: 10.1186/s12970-019-0318-3.