PMID- 31665386
OWN - NLM
STAT- MEDLINE
DCOM- 20200423
LR  - 20200630
IS  - 1349-9157 (Electronic)
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 60
IP  - 6
DP  - 2019 Nov 22
TI  - Inflammatory profile dysregulation in nuclear workers occupationally exposed to 
      low-dose gamma radiation.
PG  - 768-779
LID - 10.1093/jrr/rrz059 [doi]
AB  - Chronic inflammation is a common denominator linking a wide range of health 
      conditions, including tissue response to radiation exposure. This pilot study 
      investigates whether inflammatory cytokines-interleukins IL-6, -8, -10, monocyte 
      chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNFalpha)-can be used 
      as early biomarkers of radiation-induced adverse health effects in occupationally 
      exposed individuals. The study included 33 workers externally exposed to gamma 
      radiation from the nuclear industry with cumulated doses from 0.11 to 190 mSv and 
      42 non-exposed controls of comparable age and socio-economic status. IL-6, IL-8, 
      MCP-1, TNFalpha and IL-10 were analyzed by enzyme-linked assay (ELISA) in blood 
      plasma samples. Total antioxidant status (TAS) of blood plasma was determined by 
      a colorimetric assay. The radiation-exposed and control groups measured 
      significantly different levels of MCP-1, TNFalpha and IL-10. Seventy-five percent of 
      radiation workers had either high MCP-1 levels or low IL-10 levels and 30% had 
      all three cytokines dysregulated. Approximately 50% of workers showed upregulated 
      antioxidant status, which appeared to compensate the pro-inflammatory cytokine 
      shift in these individuals. In contrast, only 2% of the control subjects were 
      found to have three dysregulated cytokines, and all of them measured within the 
      normal TAS range. The present study may represent an important step towards the 
      establishment of a reliable set of biomarkers for health-risk estimation in 
      population cohorts exposed to low radiation doses.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of The Japan 
      Radiation Research Society and Japanese Society for Radiation Oncology.
FAU - Aneva, Nevena
AU  - Aneva N
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Zaharieva, Elena
AU  - Zaharieva E
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Katsarska, Olya
AU  - Katsarska O
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Savova, Gergana
AU  - Savova G
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Stankova, Katia
AU  - Stankova K
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Djounova, Jana
AU  - Djounova J
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
FAU - Boteva, Rayna
AU  - Boteva R
AD  - National Center of Radiobiology and Radiation Protection (NCRRP), 1606 Sofia, 
      Bulgaria.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
SB  - IM
EIN - J Radiat Res. 2020 Jan 23;61(1):169. PMID: 31748796
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - Dose-Response Relationship, Radiation
MH  - *Gamma Rays
MH  - Humans
MH  - Hypertension/blood
MH  - Inflammation/*pathology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Nuclear Power Plants
MH  - Occupational Exposure/*analysis
MH  - Radiation Exposure/*analysis
PMC - PMC7268544
OTO - NOTNLM
OT  - NOD-like receptor protein 4
OT  - biomarkers
OT  - chronic radiation exposure
OT  - inflammatory cytokines
OT  - low-dose radiation
OT  - nuclear workers
OT  - occupational exposure
EDAT- 2019/10/31 06:00
MHDA- 2020/04/24 06:00
PMCR- 2019/10/28
CRDT- 2019/10/31 06:00
PHST- 2019/04/06 00:00 [received]
PHST- 2019/06/10 00:00 [revised]
PHST- 2019/08/02 00:00 [accepted]
PHST- 2019/10/31 06:00 [pubmed]
PHST- 2020/04/24 06:00 [medline]
PHST- 2019/10/31 06:00 [entrez]
PHST- 2019/10/28 00:00 [pmc-release]
AID - 5607839 [pii]
AID - rrz059 [pii]
AID - 10.1093/jrr/rrz059 [doi]
PST - ppublish
SO  - J Radiat Res. 2019 Nov 22;60(6):768-779. doi: 10.1093/jrr/rrz059.