PMID- 31666577
OWN - NLM
STAT- MEDLINE
DCOM- 20201029
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Oct 30
TI  - Late Gadolinium Enhancement Predicts Improvement in Global Longitudinal Strain 
      after Aortic Valve Replacement in Aortic Stenosis.
PG  - 15688
LID - 10.1038/s41598-019-51930-2 [doi]
LID - 15688
AB  - Myocardial fibrosis, as detected by late gadolinium enhancement (LGE) magnetic 
      resonance imaging (MRI), is related to mortality after aortic valve replacement 
      (AVR). This study aimed to determine whether LGEMRI predicts improvement in 
      global longitudinal strain (GLS) after AVR in patients with severe aortic 
      stenosis (AS). Twenty-nine patients with severe AS who were scheduled to undergo 
      AVR were enrolled. Two-dimensional echocardiography and contrast-enhanced MRI 
      were performed before AVR. GLS and LGEcore (g: > 5 SD of normal area), LGEgray 
      (g: 2-5 SD), and LGEcore+gray (g) were measured. One year after AVR, GLS were 
      examined by echocardiography to assess improvement in LV function. 
      Preoperatively, GLS correlated with LGEcore (g) (r(2) = 0.14, p < 0.05), LGEgray 
      (g) (r(2) = 0.32, p < 0.01) and LGEcore+gray (g) (r(2) = 0.36, p < 0.01). LGEcore 
      was significantly lower in patients with improved GLS after AVR 
      (GLS(1year) >/= -19.9%) compared to those with no improvement (1.34 g vs. 4.70 g, 
      p < 0.01). LGE predicts improvement in LV systolic function after AVR.
FAU - Fujimiya, Tsuyoshi
AU  - Fujimiya T
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan. tuyoshif@fmu.ac.jp.
FAU - Iwai-Takano, Masumi
AU  - Iwai-Takano M
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
FAU - Igarashi, Takashi
AU  - Igarashi T
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
FAU - Shinjo, Hiroharu
AU  - Shinjo H
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
FAU - Ishida, Keiichi
AU  - Ishida K
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
FAU - Takase, Shinya
AU  - Takase S
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
FAU - Yokoyama, Hitoshi
AU  - Yokoyama H
AD  - Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20191030
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Aortic Valve/*diagnostic imaging/physiopathology
MH  - Aortic Valve Stenosis/*diagnostic imaging/physiopathology/surgery
MH  - Cardiomyopathies/*diagnostic imaging/physiopathology/surgery
MH  - Contrast Media/administration & dosage
MH  - Echocardiography/methods
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Ventricular Function, Left
PMC - PMC6821836
COIS- The authors declare no competing interests.
EDAT- 2019/11/02 06:00
MHDA- 2020/10/30 06:00
PMCR- 2019/10/30
CRDT- 2019/11/01 06:00
PHST- 2019/03/10 00:00 [received]
PHST- 2019/10/04 00:00 [accepted]
PHST- 2019/11/01 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/10/30 06:00 [medline]
PHST- 2019/10/30 00:00 [pmc-release]
AID - 10.1038/s41598-019-51930-2 [pii]
AID - 51930 [pii]
AID - 10.1038/s41598-019-51930-2 [doi]
PST - epublish
SO  - Sci Rep. 2019 Oct 30;9(1):15688. doi: 10.1038/s41598-019-51930-2.