PMID- 31666618
OWN - NLM
STAT- MEDLINE
DCOM- 20201029
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Oct 30
TI  - The effects of intravitreal sodium iodate injection on retinal degeneration 
      following vitrectomy in rabbits.
PG  - 15696
LID - 10.1038/s41598-019-52172-y [doi]
LID - 15696
AB  - We sought to develop and characterize outer retinal degeneration induced by 
      intravitreal injection of sodium iodate (SI) after vitrectomy in rabbits. To 
      determine the effective dose of SI, the right eyes of 19 male New Zealand white 
      rabbits received an intravitreal injection of SI or sham. Based on the 
      dose-dependence results, 0.4 mg of SI in 0.05 mL of total volume was injected 
      into the right eyes of 10 rabbits at two weeks after vitrectomy. In the 
      dose-dependence study, localized retinal atrophy was observed with 0.3- and 
      0.4-mg SI injections without vitrectomy. Severe and diffuse retinal atrophy was 
      identified by spectral-domain optical coherence tomography (SD-OCT) at one month 
      after a 0.5-mg SI injection following vitrectomy. In the second experiment, 
      0.4 mg of SI in 0.05 mL was injected, and the severity of outer retinal 
      degeneration was graded as one of two types according to electroretinography 
      (ERG) response change. There was no response on ERG in complete retinal 
      degeneration, 30% of all 10 rabbits. Intravitreal injection of 0.4 mg of SI into 
      vitrectomized rabbit eyes induces diffuse outer retinal degeneration, and the 
      degree of retinal degeneration can be evaluated through in vivo ophthalmic 
      examination.
FAU - Ahn, So Min
AU  - Ahn SM
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Ahn, Jungryul
AU  - Ahn J
AD  - Department of Physiology, Chungbuk National University School of Medicine, 
      Cheongju, Korea.
FAU - Cha, Seongkwang
AU  - Cha S
AD  - Department of Physiology, Chungbuk National University School of Medicine, 
      Cheongju, Korea.
FAU - Yun, Cheolmin
AU  - Yun C
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Park, Tae Kwann
AU  - Park TK
AD  - Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College 
      of Medicine, Bucheon, Korea.
FAU - Kim, Young-Jin
AU  - Kim YJ
AD  - Medical Device Development Center, Osong Medical Innovation Foundation, Cheongju, 
      Korea.
FAU - Goo, Yong Sook
AU  - Goo YS
AD  - Department of Physiology, Chungbuk National University School of Medicine, 
      Cheongju, Korea. ysgoo@chungbuk.ac.kr.
FAU - Kim, Seong-Woo
AU  - Kim SW
AUID- ORCID: 0000-0003-0073-5800
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. 
      ksw64723@korea.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191030
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Iodates)
RN  - U558PCS5Z9 (sodium iodate)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Electroretinography
MH  - Humans
MH  - Intravitreal Injections
MH  - Iodates/*pharmacology
MH  - Rabbits
MH  - Retina/diagnostic imaging/*drug effects/pathology
MH  - Retinal Degeneration/*drug therapy/pathology/surgery
MH  - Tomography, Optical Coherence
MH  - Vitrectomy/methods
MH  - Vitreous Body/diagnostic imaging/*drug effects/surgery
PMC - PMC6821727
COIS- The authors declare no competing interests.
EDAT- 2019/11/02 06:00
MHDA- 2020/10/30 06:00
PMCR- 2019/10/30
CRDT- 2019/11/01 06:00
PHST- 2019/08/01 00:00 [received]
PHST- 2019/10/12 00:00 [accepted]
PHST- 2019/11/01 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/10/30 06:00 [medline]
PHST- 2019/10/30 00:00 [pmc-release]
AID - 10.1038/s41598-019-52172-y [pii]
AID - 52172 [pii]
AID - 10.1038/s41598-019-52172-y [doi]
PST - epublish
SO  - Sci Rep. 2019 Oct 30;9(1):15696. doi: 10.1038/s41598-019-52172-y.