PMID- 31666827
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20200108
IS  - 1844-3117 (Electronic)
IS  - 1844-122X (Print)
IS  - 1844-122X (Linking)
VI  - 12
IP  - 3
DP  - 2019 Jul-Sep
TI  - Oxidative stress and biomarker of TNF-alpha, MDA and FRAP in hypertension.
PG  - 253-259
LID - 10.25122/jml-2019-0031 [doi]
AB  - Concurrent with the misbalance of oxidizing agents and antioxidants, high blood 
      pressure is a major physical burden condition in the current scenario. Tumor 
      necrosis factor-alpha (TNF-alpha) plays a vital role in the pathogenesis of hypertension. 
      Tumor necrosis factor-alpha, inhibitor improves clinical symptoms however their 
      outcome on high blood pressure has not been investigated. We investigated the 
      inflammatory marker TNF-alpha, malondialdehyde (MDA) and ferric reducing antioxidant 
      power (FRAP) in hypertensive patients. We measured randomly blood pressure using 
      an ambulatory observe in hypertensive patients, measured systolic BP X 140 mmHg 
      and/or diastolic BP X 90 mmHg were considered hypertensive. Total 60 cases were 
      considered in the study that involves 30 hypertensive patients and 30 normal 
      control. Measurements of serum concentrations of TNF-alpha, MDA, FRAP in hypertension 
      patients was done in both the groups. Serum TNF-alpha was found to be remarkably 
      increased in study subjects as compared to normal group (r=0.32, p<0.0001*). 
      Serum MDA was also raised in hypertensive as compared to control (r=0.99**, 
      p<0.0001*). While Serum FRAP was found to be decreased in hypertensive group in 
      comparison to healthy control (r=0.23, p<0.0001*). It is concluded that high 
      blood pressure leads to generation of oxidative stress with remarkable elevation 
      of TNF-alpha and malondialdehyde levels. While reduced FRAP indicates its probable 
      role in lipid peroxidation and in the pathogenesis of hypertension.
CI  - (c)Carol Davila University Press.
FAU - Verma, Manish Kumar
AU  - Verma MK
AD  - Department of Biochemistry, G.S.V.M. Medical College Kanpur, India.
FAU - Jaiswal, Anoop
AU  - Jaiswal A
AD  - Department of Biochemistry, Moti Lal Nehru Medical College, Allahabad, India.
FAU - Sharma, Preeti
AU  - Sharma P
AD  - Department of Biochemistry, Santosh Medical College and Hospital (Santosh 
      University), Ghaziabad, India.
FAU - Kumar, Pradeep
AU  - Kumar P
AD  - Department of Biochemistry, Santosh Medical College and Hospital (Santosh 
      University), Ghaziabad, India.
FAU - Singh, Anand Narayan
AU  - Singh AN
AD  - Department of Biochemistry, G.S.V.M. Medical College Kanpur, India.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hypertension/*blood
MH  - Iron/*metabolism
MH  - Male
MH  - Malondialdehyde/*blood
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC6814874
OTO - NOTNLM
OT  - FRAP - Ferric reducing antioxidant power
OT  - MDA - Malondialdehyde
OT  - ML - Milliliter
OT  - NO - Nitric oxide
OT  - ROS - Reactive Oxygen Species
OT  - TNF-alpha - Tumor Necrosis Factor
OT  - biomarker
OT  - blood pressure
OT  - hypertension
OT  - reactive oxygen species
EDAT- 2019/11/02 06:00
MHDA- 2019/12/20 06:00
PMCR- 2019/09/01
CRDT- 2019/11/01 06:00
PHST- 2019/11/01 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - JMedLife-12-253 [pii]
AID - 10.25122/jml-2019-0031 [doi]
PST - ppublish
SO  - J Med Life. 2019 Jul-Sep;12(3):253-259. doi: 10.25122/jml-2019-0031.