PMID- 31666997
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2095-4700 (Print)
IS  - 2095-6231 (Electronic)
IS  - 2095-4700 (Linking)
VI  - 7
DP  - 2019
TI  - Ankylosing spondylitis: etiology, pathogenesis, and treatments.
PG  - 22
LID - 10.1038/s41413-019-0057-8 [doi]
LID - 22
AB  - Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic 
      inflammatory autoimmune disease that mainly affects spine joints, causing severe, 
      chronic pain; additionally, in more advanced cases, it can cause spine fusion. 
      Significant progress in its pathophysiology and treatment has been achieved in 
      the last decade. Immune cells and innate cytokines have been suggested to be 
      crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 
      and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. 
      The current study reviewed the etiology and pathogenesis of AS, including 
      genome-wide association studies and cytokine pathways. This study also summarized 
      the current pharmaceutical and surgical treatment with a discussion of future 
      potential therapies.
CI  - (c) The Author(s) 2019.
FAU - Zhu, Wei
AU  - Zhu W
AD  - 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, 
      China. ISNI: 0000 0001 0662 3178. GRID: grid.12527.33
FAU - He, Xuxia
AU  - He X
AD  - 2Department of Clinical Medicine, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, 100730 Beijing, China. ISNI: 0000 0001 0662 3178. GRID: 
      grid.12527.33
FAU - Cheng, Kaiyuan
AU  - Cheng K
AD  - 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, 
      China. ISNI: 0000 0001 0662 3178. GRID: grid.12527.33
FAU - Zhang, Linjie
AU  - Zhang L
AD  - 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, 
      China. ISNI: 0000 0001 0662 3178. GRID: grid.12527.33
FAU - Chen, Di
AU  - Chen D
AD  - 3Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 
      60612 USA. ISNI: 0000 0001 0705 3621. GRID: grid.240684.c
FAU - Wang, Xiao
AU  - Wang X
AUID- ORCID: 0000-0001-6395-706X
AD  - 4Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University, 
      Baltimore, MD USA. ISNI: 0000 0001 2171 9311. GRID: grid.21107.35
FAU - Qiu, Guixing
AU  - Qiu G
AD  - 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, 
      China. ISNI: 0000 0001 0662 3178. GRID: grid.12527.33
FAU - Cao, Xu
AU  - Cao X
AD  - 4Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University, 
      Baltimore, MD USA. ISNI: 0000 0001 2171 9311. GRID: grid.21107.35
FAU - Weng, Xisheng
AU  - Weng X
AD  - 1Department of Orthopedics, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, 
      China. ISNI: 0000 0001 0662 3178. GRID: grid.12527.33
LA  - eng
PT  - Journal Article
DEP - 20190805
PL  - China
TA  - Bone Res
JT  - Bone research
JID - 101608652
PMC - PMC6804882
OTO - NOTNLM
OT  - Calcium and phosphate metabolic disorders
OT  - Pathogenesis
COIS- Competing interestsThe authors declare no competing interests.
EDAT- 2019/11/02 06:00
MHDA- 2019/11/02 06:01
PMCR- 2019/08/05
CRDT- 2019/11/01 06:00
PHST- 2018/12/27 00:00 [received]
PHST- 2019/05/20 00:00 [revised]
PHST- 2019/05/23 00:00 [accepted]
PHST- 2019/11/01 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2019/11/02 06:01 [medline]
PHST- 2019/08/05 00:00 [pmc-release]
AID - 57 [pii]
AID - 10.1038/s41413-019-0057-8 [doi]
PST - epublish
SO  - Bone Res. 2019 Aug 5;7:22. doi: 10.1038/s41413-019-0057-8. eCollection 2019.