PMID- 31667596
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20220218
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 476
IP  - 3
DP  - 2020 Mar
TI  - Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase 
      loss and homozygous deletion of CDKN2A: a case report.
PG  - 469-473
LID - 10.1007/s00428-019-02674-x [doi]
AB  - Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is 
      closely associated with asbestos exposure. Early detection and treatment are 
      critical to prolong survival of patients with MPM because of the rapid 
      progression and resistance to treatment. The recently defined malignant 
      mesothelioma in situ (MIS) has been gaining increasing attention with advances in 
      genome-based methods including fluorescence in situ hybridization (FISH) as well 
      as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male 
      with a history of asbestos exposure presenting with massive pleural effusion in 
      the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural 
      biopsy of the right side revealed a single layer of atypical mesothelial cells 
      without invasive lesions by hematoxylin and eosin staining. However, these 
      mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by 
      immunohistochemistry and homozygous deletion of CDKN2A (p16) by FISH, leading to 
      the diagnosis of MIS.
FAU - Minami, Kazuhiro
AU  - Minami K
AD  - Division of Thoracic Surgery, Kobe University Graduate School of Medicine, 7-5-2 
      Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
FAU - Jimbo, Naoe
AU  - Jimbo N
AD  - Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, 
      7-5-2 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
FAU - Tanaka, Yugo
AU  - Tanaka Y
AD  - Division of Thoracic Surgery, Kobe University Graduate School of Medicine, 7-5-2 
      Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan. 
      tanakay@med.kobe-u.ac.jp.
FAU - Hokka, Daisuke
AU  - Hokka D
AD  - Division of Thoracic Surgery, Kobe University Graduate School of Medicine, 7-5-2 
      Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
FAU - Miyamoto, Yoshifumi
AU  - Miyamoto Y
AD  - Division of Thoracic Surgery, Hyogo-Chuo National Hospital, 1314 Ohara, Sanda 
      City, Hyogo Prefecture, 669-1592, Japan.
FAU - Itoh, Tomoo
AU  - Itoh T
AD  - Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, 
      7-5-2 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
FAU - Maniwa, Yoshimasa
AU  - Maniwa Y
AD  - Division of Thoracic Surgery, Kobe University Graduate School of Medicine, 7-5-2 
      Kusunoki-cho, Chuo-ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20191030
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - EC 2.4.2.1 (Purine-Nucleoside Phosphorylase)
RN  - EC 2.4.2.28 (5'-methylthioadenosine phosphorylase)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Cyclin-Dependent Kinase Inhibitor p16/analysis/genetics
MH  - *Early Diagnosis
MH  - Genes, p16
MH  - Humans
MH  - Lung Neoplasms/*diagnosis
MH  - Male
MH  - Mesothelioma/*diagnosis
MH  - Mesothelioma, Malignant
MH  - Pleural Neoplasms/*diagnosis
MH  - Purine-Nucleoside Phosphorylase/analysis/biosynthesis
MH  - Sequence Deletion
OTO - NOTNLM
OT  - Fluorescence in situ hybridization
OT  - Homozygous deletion of CDKN2A (p16)
OT  - Immunohistochemistry
OT  - Malignant mesothelioma in situ
OT  - Methylthioadenosine phosphorylase
EDAT- 2019/11/02 06:00
MHDA- 2020/03/31 06:00
CRDT- 2019/11/01 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/09/22 00:00 [accepted]
PHST- 2019/09/04 00:00 [revised]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2019/11/01 06:00 [entrez]
AID - 10.1007/s00428-019-02674-x [pii]
AID - 10.1007/s00428-019-02674-x [doi]
PST - ppublish
SO  - Virchows Arch. 2020 Mar;476(3):469-473. doi: 10.1007/s00428-019-02674-x. Epub 
      2019 Oct 30.