PMID- 31668138
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 26
IP  - 14
DP  - 2020 Dec
TI  - Safety, feasibility, acceptability and effects of a behaviour-change intervention 
      to change physical activity behaviour among people with multiple sclerosis: 
      Results from the iStep-MS randomised controlled trial.
PG  - 1907-1918
LID - 10.1177/1352458519886231 [doi]
AB  - BACKGROUND: There is limited information regarding the safety, feasibility and 
      acceptability of behaviour-change interventions to increase physical activity 
      (PA) and reduce sedentary behaviour among people with multiple sclerosis (MS). 
      Prior to evaluating efficacy, it is important to identify problems with 
      feasibility and acceptability, which may undermine effectiveness. OBJECTIVE: To 
      examine the safety, feasibility and acceptability of a behaviour-change 
      intervention to increase PA and reduce sedentary behaviour among people with MS. 
      METHODS: Sixty people received a 3-month intervention or usual care. Fatigue, 
      pain and adverse events (AEs) were assessed. Feasibility and acceptability were 
      explored through focus groups with physiotherapists and interviews with 
      participants. Fidelity to intervention content, delivery skills, programme 
      receipt and programme task were assessed. RESULTS: There was no difference in AE 
      rate between groups (p = 0.965). Fatigue and pain were not higher in the 
      intervention group at 3 or 9 months. Therapists reported the intervention was 
      feasible to deliver and fidelity was acceptable. Twenty-nine participants (97%) 
      attended at least 75% of sessions. Participants found the intervention acceptable 
      but suggested some amendments were required to intervention components. 
      CONCLUSIONS: The intervention was safe, feasible and acceptable. Although 
      modifications are required to intervention components, the intervention warrants 
      further evaluation in a future trial.
FAU - Ryan, Jennifer M
AU  - Ryan JM
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK/Department of Epidemiology and Public Health 
      Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
FAU - Fortune, Jennifer
AU  - Fortune J
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Stennett, Andrea
AU  - Stennett A
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Kilbride, Cherry
AU  - Kilbride C
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Lavelle, Grace
AU  - Lavelle G
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Hendrie, Wendy
AU  - Hendrie W
AD  - MS Therapy Centre, Norwich, UK.
FAU - DeSouza, Lorraine
AU  - DeSouza L
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Abdul, Mohammed
AU  - Abdul M
AD  - The Berkshire MS Therapy Centre, Reading, UK.
FAU - Brewin, Debbie
AU  - Brewin D
AD  - Health Economics Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - David, Lee
AU  - David L
AD  - Health Economics Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Anokye, Nana
AU  - Anokye N
AD  - 10 Minute CBT, Letchworth Garden City, UK.
FAU - Victor, Christina
AU  - Victor C
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
FAU - Norris, Meriel
AU  - Norris M
AD  - Ageing Studies Theme, Institute of Environment, Health and Societies, Brunel 
      University London, London, UK.
LA  - eng
SI  - ISRCTN/ISRCTN15343862
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20191031
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Exercise
MH  - Exercise Therapy
MH  - Feasibility Studies
MH  - Humans
MH  - *Multiple Sclerosis/therapy
MH  - Sedentary Behavior
OTO - NOTNLM
OT  - Clinical trial
OT  - fatigue
OT  - multiple sclerosis
OT  - pain
OT  - rehabilitation
EDAT- 2019/11/02 06:00
MHDA- 2021/09/25 06:00
CRDT- 2019/11/01 06:00
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2019/11/01 06:00 [entrez]
AID - 10.1177/1352458519886231 [doi]
PST - ppublish
SO  - Mult Scler. 2020 Dec;26(14):1907-1918. doi: 10.1177/1352458519886231. Epub 2019 
      Oct 31.