PMID- 31668794
OWN - NLM
STAT- MEDLINE
DCOM- 20211007
LR  - 20211204
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 54
IP  - 2
DP  - 2021 Apr
TI  - Risk factors of tuberculosis after liver transplant in a tertiary care hospital.
PG  - 312-318
LID - S1684-1182(19)30139-2 [pii]
LID - 10.1016/j.jmii.2019.08.006 [doi]
AB  - BACKGROUND: Tuberculosis (TB) is a serious opportunistic infection in liver 
      transplant (LT) recipients with a high rate of morbidity and mortality. This 
      study aims to clarify the frequency and risk factors for tuberculosis in LT 
      recipients. METHODS: A total of 884 LT recipients were investigated 
      retrospectively at China Medical University Hospital, Taichung, Taiwan. We 
      performed a case-control study (1:2) to investigate the potential risk factors 
      and disease onset of TB after LT. RESULTS: Among the 884 LT recipients, 25 of TB 
      cases (2.8%) were reported from 2009 to 2016. The overall incidence of TB was 744 
      cases per 100,000 patient-year, which was 18-fold higher than the general 
      population in Taiwan. The median time to develop TB after liver transplant was 20 
      months. Of the TB cases, 15 were pulmonary TB and 10 were extra-pulmonary TB. 
      Five cases of those extra-pulmonary TB occurred in the first post-transplant 
      year. Overall five-year survival rate was 63.3%. Multivariate analyses identified 
      apical fibrotic change in pre-transplant computed tomographic (CT) finding and 
      the exposure to mammalian target of rapamycin (mTOR) inhibitors before TB event 
      as independent risk factors for TB development (Odd ratio (OR) 10.79, 95% 
      confidence interval (CI), 1.73-67.49, p = 0.01; OR 3.847, 95% CI 0.80-18.51, 
      P = 0.09, respectively). CONCLUSION: TB incidence in LT recipients is high in 
      this study. Among those post-transplant recipients with long-term 
      immunosuppression, abnormal CT finding and exposure to mTOR inhibitors before 
      liver transplant might be the risk factors for TB.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Leong, Lih-Ying
AU  - Leong LY
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Lin, Po-Chang
AU  - Lin PC
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan. Electronic address: 
      D11929@mail.cmuh.org.tw.
FAU - Chi, Chih-Yu
AU  - Chi CY
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Chou, Chia-Huei
AU  - Chou CH
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Lu, Min-Chi
AU  - Lu MC
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Liao, Wei-Chih
AU  - Liao WC
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Ho, Mao-Wang
AU  - Ho MW
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Wang, Jen-Hsien
AU  - Wang JH
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Jeng, Long-Bin
AU  - Jeng LB
AD  - Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20191008
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - TOR Serine-Threonine Kinases/drug effects
MH  - Taiwan/epidemiology
MH  - *Tertiary Care Centers
MH  - Transplant Recipients
MH  - Tuberculosis/*epidemiology
MH  - Tuberculosis, Pulmonary/epidemiology
OTO - NOTNLM
OT  - Liver transplantation
OT  - Mycobacterium tuberculosis
OT  - Risk factors
EDAT- 2019/11/02 06:00
MHDA- 2021/10/08 06:00
CRDT- 2019/11/01 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/08/12 00:00 [revised]
PHST- 2019/08/14 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2021/10/08 06:00 [medline]
PHST- 2019/11/01 06:00 [entrez]
AID - S1684-1182(19)30139-2 [pii]
AID - 10.1016/j.jmii.2019.08.006 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2021 Apr;54(2):312-318. doi: 
      10.1016/j.jmii.2019.08.006. Epub 2019 Oct 8.