PMID- 31669926
OWN - NLM
STAT- MEDLINE
DCOM- 20200514
LR  - 20220316
IS  - 2210-7797 (Electronic)
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 18
DP  - 2019 Oct
TI  - The Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia exhibits 
      impaired systolic function and global longitudinal strain during pregnancy.
PG  - 169-172
LID - S2210-7789(19)30449-0 [pii]
LID - 10.1016/j.preghy.2019.10.001 [doi]
AB  - BACKGROUND: Preeclampsia (PE) is a disorder prevalent in 3-8% of pregnancies, 
      characterized by hypertension, endothelial dysfunction and cardiac dysfunction, 
      including hypertrophy and impaired global longitudinal strain (GLS), which 
      indicates reduced contractility and tissue injury. Despite several clinical 
      studies highlighting impaired cardiac function in these women, the underlying 
      mechanisms have not been studied, in part, due to lack of an appropriate animal 
      model. The Reduced Uterine Perfusion Pressure (RUPP) rat model produces a PE-like 
      phenotype, including adverse cardiac remodeling. However, whether this translates 
      to impaired cardiac function is not known. The aim of this study was to test the 
      hypothesis that placental ischemia in the RUPP rat leads to impaired left 
      ventricular (LV) systolic function and GLS. STUDY DESIGN: RUPP (n = 10) rats 
      underwent surgery to induce placental ischemia on gestational day (GD) 14. Sham 
      (n = 10) and RUPP rats had indwelling carotid catheters placed on GD 18, and 
      blood pressure and echocardiography measurements were made on GD 19. RESULTS: The 
      RUPP group exhibited increased mean arterial pressure compared to the Sham group 
      (123 +/- 3 vs. 97 +/- 2 mmHg, P < 0.01). RUPP hearts exhibited impaired LV ejection 
      fraction (60 +/- 2 vs. 78 +/- 2%, P < 0.01) and GLS (-17.89 +/- 0.5 vs. -26.31 +/- 2.7%, 
      P = 0.02), in addition to cardiac hypertrophy (0.97 +/- 0.04 vs. 0.91 +/- 0.02 g, 
      P = 0.02). CONCLUSIONS: Cardiac dysfunction and impaired strain are present in 
      RUPP rats during pregnancy. These findings represent an animal model of PE that 
      could be used to understand the mechanisms of cardiac dysfunction in this disease 
      and ultimately, improve or prevent cardiac abnormalities in these patients.
CI  - Copyright (c) 2019 International Society for the Study of Hypertension in 
      Pregnancy. Published by Elsevier B.V. All rights reserved.
FAU - Bakrania, Bhavisha A
AU  - Bakrania BA
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS, United States. Electronic address: bbakrania@umc.edu.
FAU - Hall, Michael E
AU  - Hall ME
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS, United States; Department of Medicine, University of 
      Mississippi Medical Center, Jackson, MS, United States.
FAU - Shahul, Sajid
AU  - Shahul S
AD  - Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, 
      United States.
FAU - Granger, Joey P
AU  - Granger JP
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS, United States.
LA  - eng
GR  - K08 DK099415/DK/NIDDK NIH HHS/United States
GR  - P20 GM104357/GM/NIGMS NIH HHS/United States
GR  - U54 GM115428/GM/NIGMS NIH HHS/United States
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - T32 HL105324/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20191024
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Ischemia/physiopathology
MH  - Pre-Eclampsia/*physiopathology
MH  - Pregnancy
MH  - Pulsatile Flow
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Uterus/physiopathology
MH  - Ventricular Dysfunction, Left/*physiopathology
PMC - PMC7063592
MID - NIHMS1063151
OTO - NOTNLM
OT  - Cardiac dysfunction
OT  - Echocardiography
OT  - Placental ischemia
OT  - Preeclampsia
OT  - Speckle tracking
EDAT- 2019/11/02 06:00
MHDA- 2020/05/15 06:00
PMCR- 2020/10/24
CRDT- 2019/11/01 06:00
PHST- 2019/08/26 00:00 [received]
PHST- 2019/09/30 00:00 [revised]
PHST- 2019/10/11 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/05/15 06:00 [medline]
PHST- 2019/11/01 06:00 [entrez]
PHST- 2020/10/24 00:00 [pmc-release]
AID - S2210-7789(19)30449-0 [pii]
AID - 10.1016/j.preghy.2019.10.001 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2019 Oct;18:169-172. doi: 10.1016/j.preghy.2019.10.001. Epub 
      2019 Oct 24.