PMID- 31670376
OWN - NLM
STAT- MEDLINE
DCOM- 20200924
LR  - 20200924
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 11
DP  - 2019 Nov 29
TI  - Homocysteine and psoriasis.
LID - 10.1042/BSR20190867 [doi]
LID - BSR20190867
AB  - Psoriasis is caused by a complex interplay among the immune system, genetic 
      background, autoantigens, and environmental factors. Recent studies have 
      demonstrated that patients with psoriasis have a significantly higher serum 
      homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). 
      Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. 
      Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis 
      by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T 
      cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the 
      production of the pro-inflammatory cytokines in related to psoriasis. Hcy can 
      induce nuclear factor kappa B activation, which is critical in the 
      immunopathogenesis of psoriasis. There may be a link between the oxidative stress 
      state in psoriasis and the effect of HHcy. Hydrogen sulfide (H2S) may play a 
      protective role in the pathogenesis of psoriasis and the deficiency of H2S in 
      psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of 
      psoriasis is most likely established, Hcy can be a potential therapeutic target 
      for the treatment of psoriasis. Systemic folinate calcium, a folic acid 
      derivative, and topical vitamin B12 have found to be effective in treating 
      psoriasis.
CI  - (c) 2019 The Author(s).
FAU - Lin, Xiran
AU  - Lin X
AD  - Department of Dermatology, the First Affiliated Hospital of Dalian Medical 
      University. 222 Zhongshan Lu, Dalian 116011, China.
FAU - Meng, Xianmin
AU  - Meng X
AD  - Department of Pathology and laboratory medicine, Axia Women's Health. 450.Cresson 
      BLVD. Oaks, PA 19456, U.S.A.
FAU - Song, Zhiqi
AU  - Song Z
AD  - Department of Dermatology, the First Affiliated Hospital of Dalian Medical 
      University. 222 Zhongshan Lu, Dalian 116011, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Cytokines)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Folic Acid/pharmacology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Inflammation/blood/metabolism/pathology
MH  - Psoriasis/*blood/drug therapy/metabolism/*pathology
MH  - Vitamin B 12/pharmacology
PMC - PMC6879356
OTO - NOTNLM
OT  - folic acid
OT  - homocysteine
OT  - hydrogen sulfide
OT  - psoriasis
OT  - vitamin B12
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/11/02 06:00
MHDA- 2020/09/25 06:00
PMCR- 2019/11/22
CRDT- 2019/11/01 06:00
PHST- 2019/04/03 00:00 [received]
PHST- 2019/10/08 00:00 [revised]
PHST- 2019/10/23 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/09/25 06:00 [medline]
PHST- 2019/11/01 06:00 [entrez]
PHST- 2019/11/22 00:00 [pmc-release]
AID - 220983 [pii]
AID - BSR20190867 [pii]
AID - 10.1042/BSR20190867 [doi]
PST - ppublish
SO  - Biosci Rep. 2019 Nov 29;39(11):BSR20190867. doi: 10.1042/BSR20190867.