PMID- 31671640
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 11
IP  - 11
DP  - 2019 Oct 30
TI  - Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan 
      Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy.
LID - 10.3390/pharmaceutics11110563 [doi]
LID - 563
AB  - Japanese cedar pollinosis is a type I allergic disease and has already become a 
      major public health problem in Japan. Conventional subcutaneous immunotherapy 
      (SCIT) and sublingual immunotherapy (SLIT) cannot meet patients' needs owing to 
      the side effects caused by both the use of conventional whole antigen molecules 
      in the pollen extract and the administration routes. To address these issues, a 
      surface-modified antigen and transcutaneous administration route are introduced 
      in this research. First, the pollen extract (PE) was conjugated to galactomannan 
      (PE-GM) to mask immunoglobulin E (IgE)-binding epitopes in the PE to avoid side 
      effects. Second, as a safer alternative to SCIT and SLIT, transcutaneous 
      immunotherapy (TCIT) with a solid-in-oil (S/O) nanodispersion system carrying 
      PE-GM was proposed. Hydrophilic PE-GM was efficiently delivered through mouse 
      skin using S/O nanodispersions, reducing the antibody secretion and modifying the 
      type 1 T helper (Th1)/ type 2 T helper (Th2) balance in the mouse model, thereby 
      demonstrating the potential to alleviate Japanese cedar pollinosis.
FAU - Kong, Qingliang
AU  - Kong Q
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. kong.qingliang.445@s.kyushu-u.ac.jp.
FAU - Higasijima, Kouki
AU  - Higasijima K
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. higasijima.kouki.120@s.kyushu-u.ac.jp.
FAU - Wakabayashi, Rie
AU  - Wakabayashi R
AUID- ORCID: 0000-0003-0348-8091
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. rie_wakaba@mail.cstm.kyushu-u.ac.jp.
FAU - Tahara, Yoshiro
AU  - Tahara Y
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. ytahara@mail.doshisha.ac.jp.
FAU - Kitaoka, Momoko
AU  - Kitaoka M
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. mkitaoka@mail.cstm.kyushu-u.ac.jp.
FAU - Obayashi, Hiroki
AU  - Obayashi H
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. obayashi.hiroki.495@s.kyushu-u.ac.jp.
FAU - Hou, Yanting
AU  - Hou Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, No.103, Wenhua Road, 
      Shenyang 110016, China. hou.yanting.636@s.kyushu-u.ac.jp.
FAU - Kamiya, Noriho
AU  - Kamiya N
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. kamiya.noriho.367@m.kyushu-u.ac.jp.
AD  - Advanced Transdermal Drug Delivery System Center, Kyushu University, Fukuoka 
      819-0395, Japan;. kamiya.noriho.367@m.kyushu-u.ac.jp.
AD  - Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan. 
      kamiya.noriho.367@m.kyushu-u.ac.jp.
FAU - Goto, Masahiro
AU  - Goto M
AUID- ORCID: 0000-0002-2008-9351
AD  - Department of Applied Chemistry, Graduate School of Engineering, Kyushu 
      University, Fukuoka 819-0395, Japan. m-goto@mail.cstm.kyushu-u.ac.jp.
AD  - Advanced Transdermal Drug Delivery System Center, Kyushu University, Fukuoka 
      819-0395, Japan;. m-goto@mail.cstm.kyushu-u.ac.jp.
AD  - Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan. 
      m-goto@mail.cstm.kyushu-u.ac.jp.
LA  - eng
GR  - Scientific Research (S) 16H06369/Ministry of Education, Culture, Sports, Science, 
      and Technology of Japan/
PT  - Journal Article
DEP - 20191030
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC6920820
OTO - NOTNLM
OT  - Japanese cedar pollinosis
OT  - Nanocarrier
OT  - Pollen extract-galactomannan conjugate
OT  - Solid-in-oil nanodispersions
OT  - Transcutaneous immunotherapy
OT  - Vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/02 06:00
MHDA- 2019/11/02 06:01
PMCR- 2019/11/01
CRDT- 2019/11/02 06:00
PHST- 2019/09/20 00:00 [received]
PHST- 2019/10/24 00:00 [revised]
PHST- 2019/10/27 00:00 [accepted]
PHST- 2019/11/02 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2019/11/02 06:01 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - pharmaceutics11110563 [pii]
AID - pharmaceutics-11-00563 [pii]
AID - 10.3390/pharmaceutics11110563 [doi]
PST - epublish
SO  - Pharmaceutics. 2019 Oct 30;11(11):563. doi: 10.3390/pharmaceutics11110563.