PMID- 31671904
OWN - NLM
STAT- MEDLINE
DCOM- 20200327
LR  - 20231019
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 21
DP  - 2019 Oct 29
TI  - Antibacterial Property of Composites of Reduced Graphene Oxide with Nano-Silver 
      and Zinc Oxide Nanoparticles Synthesized Using a Microwave-Assisted Approach.
LID - 10.3390/ijms20215394 [doi]
LID - 5394
AB  - Graphene oxide (GO) composites with various metal nanoparticles (NPs) are 
      attracting increasing interest owing to their broad scope in biomedical 
      applications. Here, microwave-assisted chemical reduction was used to deposit 
      nano-silver and zinc oxide NPs (Ag and ZnO NPs) on the surface of reduced GO 
      (rGO) at the following weight percentages: 5.34% Ag/rGO, 7.49% Ag/rGO, 6.85% 
      ZnO/rGO, 16.45% ZnO/rGO, 3.47/34.91% Ag/ZnO/rGO, and 7.08/15.28% Ag/ZnO/rGO. 
      These materials were tested for antibacterial activity, and 3.47/34.91% 
      Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO exhibited better antibacterial activity 
      than the other tested materials against the gram-negative bacterium Escherichia 
      coli K12. At 1000 ppm, both these Ag/ZnO/rGO composites had better killing 
      properties against both E. coli K12 and the gram-positive bacterium 
      Staphylococcus aureus SA113 than Ag/rGO and ZnO/rGO did. RedoxSensor flow 
      cytometry showed that 3.47/34.91% Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO decreased 
      reductase activity and affected membrane integrity in the bacteria. At 100 ppm, 
      these two composites affected membrane integrity more in E. coli, while 
      7.08/15.28% Ag/ZnO/rGO considerably decreased reductase activity in S. aureus. 
      Thus, the 3.47/34.91% and 7.08%/15.28% Ag/ZnO/rGO nanocomposites can be applied 
      not only as antibacterial agents but also in a variety of biomedical materials 
      such as sensors, photothermal therapy, drug delivery, and catalysis, in the 
      future.
FAU - Hsueh, Yi-Huang
AU  - Hsueh YH
AD  - Department of Seafood Science, National Kaohsiung University of Science and 
      Technology, Kaohsiung 81143, Taiwan. yihhsueh@nkust.edu.tw.
FAU - Hsieh, Chien-Te
AU  - Hsieh CT
AD  - Department of Chemical Engineering and Materials Science, Yuan Ze University, 
      Taoyuan 32003, Taiwan. cthsieh@saturn.yzu.edu.
FAU - Chiu, Shu-Ting
AU  - Chiu ST
AD  - Department of Chemical Engineering and Materials Science, Yuan Ze University, 
      Taoyuan 32003, Taiwan. qcricnt@hotmail.com.
FAU - Tsai, Ping-Han
AU  - Tsai PH
AD  - Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan 
      32003, Taiwan. n8808701@gmail.com.
FAU - Liu, Chia-Ying
AU  - Liu CY
AD  - Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 
      220, Taiwan. chiaying.liu@gmail.com.
FAU - Ke, Wan-Ju
AU  - Ke WJ
AD  - Graduate Institute of Biomedical Sciences, and Research Center for Bacterial 
      Pathogenesis, Chang Gung University, Taoyuan 33302, Taiwan. 
      d8901005@stmail.cgu.edu.tw.
LA  - eng
GR  - 107-2221-E-155 -021 -/Ministry of Science & Technology of Taiwan, R.O.C/
PT  - Journal Article
DEP - 20191029
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (graphene oxide)
RN  - 3M4G523W1G (Silver)
RN  - 7782-42-5 (Graphite)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Anti-Bacterial Agents/chemistry/*pharmacology
MH  - Drug Delivery Systems/methods
MH  - Escherichia coli/drug effects
MH  - Graphite/chemistry/*pharmacology
MH  - Metal Nanoparticles/*chemistry
MH  - Microbial Sensitivity Tests
MH  - Microscopy, Electron, Scanning
MH  - Microwaves
MH  - Nanocomposites/chemistry
MH  - Particle Size
MH  - Silver/chemistry/*pharmacology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Staphylococcus aureus/drug effects
MH  - X-Ray Diffraction
MH  - Zinc Oxide/chemistry/*pharmacology
PMC - PMC6862684
OTO - NOTNLM
OT  - Escherichia coli
OT  - Staphylococcus aureus
OT  - antibacterial agents
OT  - graphene
OT  - minimum inhibitory concentration
OT  - nano-silver
OT  - nanocomposite
OT  - sterilization
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/02 06:00
MHDA- 2020/03/28 06:00
PMCR- 2019/11/01
CRDT- 2019/11/02 06:00
PHST- 2019/09/03 00:00 [received]
PHST- 2019/10/28 00:00 [revised]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/11/02 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/03/28 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - ijms20215394 [pii]
AID - ijms-20-05394 [pii]
AID - 10.3390/ijms20215394 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Oct 29;20(21):5394. doi: 10.3390/ijms20215394.