PMID- 31672500
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20200228
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 158
DP  - 2019 Dec
TI  - Relationship between glucose variability evaluated by continuous glucose 
      monitoring and clinical factors, including glucagon-stimulated insulin secretion 
      in patients with type 2 diabetes.
PG  - 107904
LID - S0168-8227(19)30571-6 [pii]
LID - 10.1016/j.diabres.2019.107904 [doi]
AB  - AIMS: To evaluate the clinical factors affecting daily and day-to-day glucose 
      variability by using continuous glucose monitoring. METHODS: We performed a 
      cross-sectional analysis of patients with type 2 diabetes mellitus (T2DM) who 
      underwent a glucagon stimulation test (GST) with 72 h of continuous glucose 
      monitoring. Daily glucose variability was evaluated by mean amplitude of glycemic 
      excursions [MAGE], percentage coefficient of variation for glucose (%CV), and 
      day-to-day glucose variability (mean of daily differences [MODD]) by using 
      continuous glucose monitoring. Correlations of clinical factors, including 
      insulin secretion ability by the GST with MAGE, %CV, and MODD, were analyzed. 
      RESULTS: In 83 T2DM with insulin therapy, age and hemoglobin A(1c) (HbA(1c)) 
      correlated with MAGE and %CV, fasting plasma glucose with MAGE and MODD, and 
      increment of C-peptide immunoreactivity (DeltaCPR) by GST correlated inversely with 
      MAGE, %CV, and MODD. In 126 T2DM without insulin therapy, age, diastolic blood 
      pressure, and triglycerides correlated with MODD, HbA(1c) with MAGE and MODD, and 
      DeltaCPR inversely correlated with %CV. Use of alpha-glucosidase inhibitors inversely 
      correlated with %CV, whereas that of sulfonylurea was associated with MAGE and 
      %CV. CONCLUSIONS: These results suggest that DeltaCPR correlated with stability of 
      glycemic control, whereas poorly controlled diabetes is associated with increase 
      in glucose variability. alpha-glucosidase inhibitors may be superior to sulfonylureas 
      in reducing the glucose variability in T2DM.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Ohara, Makoto
AU  - Ohara M
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan. Electronic address: 
      s6018@nms.ac.jp.
FAU - Hiromura, Munenori
AU  - Hiromura M
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Nagaike, Hiroe
AU  - Nagaike H
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Kohata, Yo
AU  - Kohata Y
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Fujikawa, Tomoki
AU  - Fujikawa T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Goto, Satoshi
AU  - Goto S
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Sato, Nobuko
AU  - Sato N
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Kushima, Hideki
AU  - Kushima H
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Terasaki, Michishige
AU  - Terasaki M
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Yamamoto, Takeshi
AU  - Yamamoto T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Mori, Yusaku
AU  - Mori Y
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Hayashi, Toshiyuki
AU  - Hayashi T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Fukui, Tomoyasu
AU  - Fukui T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Yamagishi, Sho-Ichi
AU  - Yamagishi SI
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Hirano, Tsutomu
AU  - Hirano T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan; Diabetes Center, Ebina General 
      Hospital, Ebina, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191028
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Blood Glucose Self-Monitoring/*methods
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucagon/*metabolism
MH  - Humans
MH  - Insulin Secretion/*physiology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Glucagon stimulation test
OT  - Glucose monitoring
OT  - Glucose variability
OT  - Type 2 diabetes mellitus
EDAT- 2019/11/02 06:00
MHDA- 2020/02/29 06:00
CRDT- 2019/11/02 06:00
PHST- 2019/05/02 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/10/25 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2019/11/02 06:00 [entrez]
AID - S0168-8227(19)30571-6 [pii]
AID - 10.1016/j.diabres.2019.107904 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Dec;158:107904. doi: 10.1016/j.diabres.2019.107904. 
      Epub 2019 Oct 28.