PMID- 31672515
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 135
DP  - 2020 Jan
TI  - The potential efficacy of dietary fatty acids and fructose induced inflammation 
      and oxidative stress on the insulin signaling and fat accumulation in mice.
PG  - 110914
LID - S0278-6915(19)30704-5 [pii]
LID - 10.1016/j.fct.2019.110914 [doi]
AB  - The aim of the present study was to clarify whether oxidative stress and 
      inflammatory responses are related to impaired insulin signaling and fat 
      accumulation induced by the dietary fatty acids and fructose. C57BL/6 type 8 
      week-old male mice (n = 10/per group) were fed with standard chow or three 
      isocaloric diets consisting fructose, monounsaturated fatty acids (MUFA), or 
      saturated fatty acid (SFA) for 15 weeks. After the dietary manipulation, the mice 
      were sacrificed, tissues and blood were collected. Consequently, body weight 
      gains, liver weights, and plasma homeostasis model of assessment-insulin 
      resistance (HOMA-IR) values in were at higher levels in SFA and fructose groups 
      (p < 0.05). The plasma concentrations of the non-esterified fatty acids (NEFA), 
      triglyceride (TG), and liver steatosis were found to be at higher levels in SFA 
      and fructose groups (p < 0.05). Moreover, the expression levels of acetyl-CoA 
      carboxylase-1 (ACC1), insulin receptor substrate-1 (IRS1), AMP-activated protein 
      kinase (AMPK), and toll-like receptor-4 (TLR4) in the liver were affected by the 
      intake of SFA and fructose. Furthermore, the plasma levels of C-reactive protein 
      (CRP) and monocyte chemoattractant protein-1 (MCP1) and the thiobarbituric acid 
      reactive substances (TBARS) in the liver were elevated in SFA and fructose group 
      (p < 0.05). The plasma level of anti-inflammatory cytokine interleukin-10 (IL 
      -10) was found to be lower in the SFA group compared to the other groups 
      (p < 0.05). In conclusion, the inflammation and oxidation are related with the 
      fatty acid- and fructose-induced impaired insulin signaling and fat accumulation 
      in liver. Hence, in order to decrease the oxidative stress and pro-inflammatory 
      response, it is substantial to reduce the saturated fat and added sugar or to 
      replace with the unsaturated fat and complex carbohydrates in diet.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Tamer, Funda
AU  - Tamer F
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe 
      University, Ankara, 06100, Turkey. Electronic address: fundat@hacettepe.edu.tr.
FAU - Ulug, Elif
AU  - Ulug E
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe 
      University, Ankara, 06100, Turkey. Electronic address: 
      elif.ugur@hacettepe.edu.tr.
FAU - Akyol, Aytekin
AU  - Akyol A
AD  - Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, 
      06100, Turkey; Transgenic Animal Technologies Research and Application Center, 
      Hacettepe University, Ankara, 06100, Turkey. Electronic address: 
      akyol.aytekin@gmail.com.
FAU - Nergiz-Unal, Reyhan
AU  - Nergiz-Unal R
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe 
      University, Ankara, 06100, Turkey. Electronic address: rnergiz@hacettepe.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20191028
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cytokines/metabolism
MH  - Diet
MH  - Fatty Acids, Monounsaturated/*adverse effects
MH  - Fatty Liver/chemically induced/*metabolism
MH  - Fructose/*adverse effects
MH  - Inflammation/chemically induced/*metabolism
MH  - Insulin Resistance/physiology
MH  - Lipid Peroxidation/drug effects
MH  - Liver/metabolism/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Organ Size/drug effects
MH  - Oxidative Stress/*drug effects
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - Fructose
OT  - Inflammation
OT  - Insulin resistance
OT  - Lipogenesis
OT  - Oxidative stress
OT  - Saturated fatty acids
EDAT- 2019/11/02 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/11/02 06:00
PHST- 2019/05/31 00:00 [received]
PHST- 2019/10/17 00:00 [revised]
PHST- 2019/10/23 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/11/02 06:00 [entrez]
AID - S0278-6915(19)30704-5 [pii]
AID - 10.1016/j.fct.2019.110914 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Jan;135:110914. doi: 10.1016/j.fct.2019.110914. Epub 2019 
      Oct 28.