PMID- 31672559
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1885-5857 (Electronic)
IS  - 1885-5857 (Linking)
VI  - 73
IP  - 9
DP  - 2020 Sep
TI  - Clinical and genetic differences between heterozygous familial 
      hypercholesterolemia patients with and without type 2 diabetes.
PG  - 718-724
LID - S1885-5857(19)30262-2 [pii]
LID - 10.1016/j.rec.2019.09.001 [doi]
AB  - INTRODUCTION AND OBJECTIVES: The lower prevalence of type 2 diabetes mellitus 
      (T2DM) in patients with heterozygous familial hypercholesterolemia (HeFH) could 
      explain why T2DM has not always been identified as an independent predictor of 
      cardiovascular disease (CVD) in different familial hypercholesterolemia cohort 
      studies. The aim of the present study was to evaluate clinical and genetic 
      aspects of HeFH patients with T2DM in the dyslipidemia registry of the Spanish 
      Arteriosclerosis Society. METHODS: HeFH patients were classified according to the 
      presence or absence of T2DM. The clinical, biochemical and genetic 
      characteristics of the 2 groups were compared. RESULTS: Of the 2301 patients with 
      primary hypercholesterolemia included in the registry, 1724 with a probable or 
      definite diagnosis according to the Dutch Lipid Clinic Network score were finally 
      included. HeFH patients with T2DM had a higher rate of CVD and a less favorable 
      lipid profile, with higher total cholesterol (366.9+/-86.7mg/dL vs 342.0+/-74.7mg/dL; 
      mean difference 24.894; 95%CI, 5.840-43.949) and non-high-density lipoprotein 
      cholesterol (316.9+/-87.8mg/dL vs 286.4+/-75.4mg/dL; mean difference 30.500; 95%CI, 
      11.211-49.790) levels. No significant differences were found between the groups 
      concerning the specific type of HeFH-causing mutation (P=.720). After adjustment 
      for major risk factors, logistic regression analysis confirmed a relationship 
      between T2DM and the presence of CVD (OR, 2.01; 95%CI, 1.18-3.43; P=.010). 
      CONCLUSIONS: HeFH patients with T2DM have a higher rate of CVD and a less 
      favorable lipid profile, regardless of genetic mutation type. In these patients, 
      T2DM is associated with the presence of CVD.
CI  - Copyright (c) 2019 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, 
      S.L.U. All rights reserved.
FAU - Climent, Elisenda
AU  - Climent E
AD  - Servicio Endocrinologia y Nutricion, Hospital del Mar, Barcelona, Spain; 
      Departamento de Medicina, Universitat Autonoma de Barcelona, Campus Universitari 
      Mar, Barcelona, Spain.
FAU - Perez-Calahorra, Sofia
AU  - Perez-Calahorra S
AD  - Unidad Clinica e Investigacion en Lipidos y Arteriosclerosis, Hospital 
      Universitario Miguel Servet, IIS Aragon, CIBERCV, Zaragoza, Spain.
FAU - Benaiges, David
AU  - Benaiges D
AD  - Servicio Endocrinologia y Nutricion, Hospital del Mar, Barcelona, Spain; 
      Departamento de Medicina, Universitat Autonoma de Barcelona, Campus Universitari 
      Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mediques 
      (IMIM), Barcelona, Spain.
FAU - Pinto, Xavier
AU  - Pinto X
AD  - Unidad de Lipidos y Riesgo Cardiovascular, Servicio de Medicina Interna, Hospital 
      Universitario Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Suarez-Tembra, Manuel
AU  - Suarez-Tembra M
AD  - Unidad de Lipidos y Riesgo Cardiovascular, Hospital San Rafael, A Coruna, Spain.
FAU - Plana, Nuria
AU  - Plana N
AD  - Unidad de Lipidos (UVASMET), Hospital San Joan de Reus, Tarragona, Spain.
FAU - Sanchez-Hernandez, Rosa M
AU  - Sanchez-Hernandez RM
AD  - Unidad de Lipidos, Hospital Universitario Insular, Las Palmas de Gran Canaria, 
      Las Palmas, Spain.
FAU - Valdivielso, Pedro
AU  - Valdivielso P
AD  - Unidad de Lipidos, Hospital Universitario Virgen de la Victoria, Malaga, Spain.
FAU - Ascaso, Juan F
AU  - Ascaso JF
AD  - Unidad de Lipidos, Hospital Clinico Universitario de Valencia, Valencia, Spain.
FAU - Pedro-Botet, Juan
AU  - Pedro-Botet J
AD  - Servicio Endocrinologia y Nutricion, Hospital del Mar, Barcelona, Spain; 
      Departamento de Medicina, Universitat Autonoma de Barcelona, Campus Universitari 
      Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mediques 
      (IMIM), Barcelona, Spain. Electronic address: 86620@parcdesalutmar.cat.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20191028
PL  - Spain
TA  - Rev Esp Cardiol (Engl Ed)
JT  - Revista espanola de cardiologia (English ed.)
JID - 101587954
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/genetics
MH  - Heterozygote
MH  - Humans
MH  - *Hypercholesterolemia
MH  - Hyperlipoproteinemia Type II/complications/diagnosis/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Diabetes mellitus tipo 2
OT  - Enfermedad cardiovascular
OT  - Factores geneticos
OT  - Genetic factors
OT  - Heterozygous familial hypercholesterolemia
OT  - Hipercolesterolemia
OT  - Hipercolesterolemia familiar heterocigota
OT  - Hypercholesterolemia
OT  - Type 2 diabetes mellitus
EDAT- 2019/11/02 06:00
MHDA- 2021/04/20 06:00
CRDT- 2019/11/02 06:00
PHST- 2019/03/02 00:00 [received]
PHST- 2019/08/01 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2019/11/02 06:00 [entrez]
AID - S1885-5857(19)30262-2 [pii]
AID - 10.1016/j.rec.2019.09.001 [doi]
PST - ppublish
SO  - Rev Esp Cardiol (Engl Ed). 2020 Sep;73(9):718-724. doi: 
      10.1016/j.rec.2019.09.001. Epub 2019 Oct 28.