PMID- 31673099
OWN - NLM
STAT- MEDLINE
DCOM- 20201118
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Oct 31
TI  - Genetic variation affects binge feeding behavior in female inbred mouse strains.
PG  - 15709
LID - 10.1038/s41598-019-51874-7 [doi]
LID - 15709
AB  - Identifying genetic variants that regulate binge eating (BE) is critical for 
      understanding the factors that control this behavior and for the development of 
      pharmacological treatment strategies. Although several studies have revealed 
      specific genes capable of affecting BE behavior, less is known about how genetic 
      variation modulates BE. Thus, through a paradigm that promoted binge-like food 
      intake through intermittent access to high calorie diet (HCD), we quantified 
      food-intake in four inbred mouse strains: C57Bl/6J (B6), NOD/LtJ (NOD), 
      129S1/SvlmJ (S1), and A/J (AJ). We report that genetic variation likely 
      influences the chronic regulation of food intake and the binge-like consumption 
      of a palatable HCD. AJ mice consumed more of both standard chow and HCD than the 
      other three strains tested when both diets were available ad libitum, while S1 
      mice consumed significantly less HCD than other strains during intermittent HCD 
      access. Behavioral differences were also associated with differential changes in 
      c-Fos immunohistochemistry in brain regions traditionally associated with 
      appetite regulation. Our results identify 129S1/SvlmJ as a strain that exhibits 
      low levels of binge feeding behavior and suggests that this strain could be 
      useful in the investigation of the influence of genetic variation in the control 
      of binge food intake.
FAU - Newmyer, Brandon A
AU  - Newmyer BA
AD  - Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
FAU - Whindleton, Ciarra M
AU  - Whindleton CM
AD  - Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
FAU - Srinivasa, Nandan
AU  - Srinivasa N
AD  - Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
FAU - Jones, Marieke K
AU  - Jones MK
AUID- ORCID: 0000-0001-5045-6725
AD  - Health Sciences Library, University of Virginia, Charlottesville, VA, USA.
FAU - Scott, Michael M
AU  - Scott MM
AD  - Department of Pharmacology, University of Virginia, Charlottesville, VA, USA. 
      mms8rm@virginia.edu.
LA  - eng
PT  - Journal Article
DEP - 20191031
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
EIN - Sci Rep. 2020 Jan 14;10(1):619. PMID: 31932665
MH  - Animals
MH  - Binge-Eating Disorder/genetics
MH  - Disease Models, Animal
MH  - *Feeding Behavior
MH  - Female
MH  - *Genetic Variation
MH  - Mice
MH  - Mice, Inbred Strains
PMC - PMC6823456
COIS- The authors declare no competing interests.
EDAT- 2019/11/02 06:00
MHDA- 2020/11/20 06:00
PMCR- 2019/10/31
CRDT- 2019/11/02 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/10/09 00:00 [accepted]
PHST- 2019/11/02 06:00 [entrez]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2019/10/31 00:00 [pmc-release]
AID - 10.1038/s41598-019-51874-7 [pii]
AID - 51874 [pii]
AID - 10.1038/s41598-019-51874-7 [doi]
PST - epublish
SO  - Sci Rep. 2019 Oct 31;9(1):15709. doi: 10.1038/s41598-019-51874-7.