PMID- 31674662
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20201123
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 189
IP  - 1
DP  - 2020 Apr
TI  - Human leukocyte antigen (HLA) class I antibodies and transfusion support in 
      paediatric HLA-matched haematopoietic cell transplant for sickle cell disease.
PG  - 162-170
LID - 10.1111/bjh.16298 [doi]
AB  - The relevance of donor-specific human leukocyte antigen (HLA) antibodies in 
      HLA-mismatched haematopoietic cell transplant (HCT) is known, but the importance 
      of HLA antibodies in HLA-matched HCT is unclear. We hypothesized that HLA 
      antibodies detected before HCT would cause platelet transfusion refractoriness 
      during HCT and investigated this in a multi-centre study. Pre-HCT samples from 45 
      paediatric patients with sickle cell disease (SCD) undergoing HLA-matched HCT 
      were tested for HLA class I antibodies. The number of platelet transfusions 
      received before day +45 was compared between those with and without antibodies. 
      Thirteen of 45 (29%) patients had a positive HLA class I antibody screen, and 
      these patients received significantly more platelet transfusions than patients 
      without antibodies (median 19 vs. 7.5, P = 0.028). This platelet transfusion 
      association remained significant when controlling for conditioning regimen. Among 
      alloimmunized patients, there was no association between the panel-reactive 
      antibody and the number of platelet transfusions. Patients with HLA class I 
      antibodies also had a higher incidence of acute graft-versus-host disease (GVHD): 
      6/13 (46%) vs. 3/32 (9%), P = 0.011. Pre-HCT HLA class I alloimmunization is 
      associated with increased platelet transfusion support and acute GVHD in 
      paediatric HLA-matched HCT for SCD. Further studies are needed to investigate the 
      pathobiology of this association.
CI  - (c) 2019 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Nickel, Robert S
AU  - Nickel RS
AUID- ORCID: 0000-0003-4277-7523
AD  - Division of Hematology, Children's National Hospital, Washington, DC, USA.
AD  - The George Washington University School of Medicine and Health Sciences, 
      Washington, DC, USA.
FAU - Horan, John T
AU  - Horan JT
AD  - Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, USA.
FAU - Abraham, Allistair
AU  - Abraham A
AUID- ORCID: 0000-0003-2019-0887
AD  - Division of Hematology, Children's National Hospital, Washington, DC, USA.
AD  - The George Washington University School of Medicine and Health Sciences, 
      Washington, DC, USA.
FAU - Qayed, Muna
AU  - Qayed M
AD  - Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, USA.
FAU - Haight, Ann
AU  - Haight A
AD  - Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, USA.
FAU - Ngwube, Alexander
AU  - Ngwube A
AD  - Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, 
      USA.
FAU - Liang, Hua
AU  - Liang H
AD  - Department of Statistics, The George Washington University, Washington, DC, USA.
FAU - Luban, Naomi L C
AU  - Luban NLC
AD  - Division of Hematology, Children's National Hospital, Washington, DC, USA.
AD  - The George Washington University School of Medicine and Health Sciences, 
      Washington, DC, USA.
FAU - Hendrickson, Jeanne E
AU  - Hendrickson JE
AUID- ORCID: 0000-0002-7928-3132
AD  - Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
LA  - eng
GR  - Thrasher Research Fund/International
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191101
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Allografts
MH  - *Anemia, Sickle Cell/epidemiology/immunology/pathology/therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Graft vs Host Disease/epidemiology/etiology/immunology
MH  - HLA Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Isoantibodies/*immunology
MH  - Male
MH  - *Platelet Transfusion
OTO - NOTNLM
OT  - alloimmunization
OT  - bone marrow transplant
OT  - human leukocyte antigen
OT  - sickle cell disease
OT  - transfusion
EDAT- 2019/11/02 06:00
MHDA- 2020/11/24 06:00
CRDT- 2019/11/02 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/08/19 00:00 [accepted]
PHST- 2019/11/02 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2019/11/02 06:00 [entrez]
AID - 10.1111/bjh.16298 [doi]
PST - ppublish
SO  - Br J Haematol. 2020 Apr;189(1):162-170. doi: 10.1111/bjh.16298. Epub 2019 Nov 1.