PMID- 31675137 OWN - NLM STAT- MEDLINE DCOM- 20200921 LR - 20200921 IS - 1097-0096 (Electronic) IS - 0091-2751 (Linking) VI - 48 IP - 3 DP - 2020 Mar TI - Clinical significance of early-diastolic tissue velocity imaging of lateral mitral annulus for prognosis of nonischemic left ventricular dysfunction. PG - 160-167 LID - 10.1002/jcu.22787 [doi] AB - PURPOSE: We explored the potential of tissue velocity imaging (TVI) for prognosis of nonischemic left ventricular (LV) dysfunction (LVD). METHODS: We reviewed 138 nonischemic LVD patients (58 +/- 14 years) who underwent both cardiac magnetic resonance (CMR) and echocardiography. Septal and lateral mitral annular TVI data were compared with late gadolinium enhancement (LGE) on CMR. During a mean follow-up of 24 months, recovery (>15%) of LV ejection fraction and clinical outcomes (cardiovascular death and heart failure hospitalization) were assessed. RESULTS: LGE was commonly observed in the basal anteroseptal, inferoseptal, and inferior segments, but infrequently observed in the anterolateral segment. LGE was associated with lower early diastolic, septal (Sep-e' = 5.2 +/- 2.0 vs 6.9 +/- 2.0 cm/s, P = .031) and lateral (Lat-e' = 7.3 +/- 3.0 vs 9.5 +/- 2.0 cm/s, P < .001) TVI. The relationship between Lat-e' and anterolateral LGE (area under the curve, AUC 0.834) was much better than that between Sep-e' and inferoseptal LGE (AUC 0.699). The 60 patients with LVD reversibility revealed higher Lat-e' (9.8 +/- 2.0 vs 6.7 +/- 2.2 cm/s, P < .001) and lower LGE burden (7.3 +/- 9.0 vs 22 +/- 10%, P < .001), while Lat-e'