PMID- 31676092
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20230208
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 215
IP  - 12
DP  - 2019 Dec
TI  - Dendritic cells in pancreatic cancer immunotherapy: Vaccines and combination 
      immunotherapies.
PG  - 152691
LID - S0344-0338(19)31840-0 [pii]
LID - 10.1016/j.prp.2019.152691 [doi]
AB  - Despite significant advances over the past decades of research, pancreatic cancer 
      (PC) continues to have the worst 5-year survival of any malignancy. Dendritic 
      cells (DCs) are the most potent professional antigen-presenting cells and are 
      involved in the induction and regulation of antitumor immune responses. DC-based 
      immunotherapy has been used in clinical trials for PC. Although safety, efficacy, 
      and immune activation were reported in patients with PC, DC vaccines have not yet 
      fulfilled their promise. Additional strategies for combinatorial approaches aimed 
      to augment and sustain the antitumor specific immune response elicited by DC 
      vaccines are currently being investigated. Here, we will discuss DC vaccination 
      immunotherapies that are currently under preclinical and clinical investigation 
      and potential combination approaches for treating and improving the survival of 
      PC patients.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Yang, Jia
AU  - Yang J
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL, USA.
FAU - Shangguan, Junjie
AU  - Shangguan J
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL, USA.
FAU - Eresen, Aydin
AU  - Eresen A
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL, USA.
FAU - Li, Yu
AU  - Li Y
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL, USA; Department of General Surgery, The Affiliated Hospital of 
      Qingdao University, Qingdao, Shandong, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Chongqing, China. Electronic 
      address: wangjian_811@yahoo.com.
FAU - Zhang, Zhuoli
AU  - Zhang Z
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern 
      University, Chicago, IL, USA. Electronic address: zhuoli-zhang@northwestern.edu.
LA  - eng
GR  - R01 CA209886/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20191017
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Antineoplastic Agents, Immunological)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Immunological/adverse effects/*therapeutic use
MH  - Cancer Vaccines/adverse effects/*therapeutic use
MH  - Chemotherapy, Adjuvant
MH  - Dendritic Cells/immunology/*transplantation
MH  - Humans
MH  - *Immunotherapy, Adoptive/adverse effects
MH  - Pancreatic Neoplasms/immunology/mortality/pathology/*therapy
MH  - Treatment Outcome
MH  - Tumor Escape
OTO - NOTNLM
OT  - Combination therapies
OT  - Dendritic cells
OT  - Pancreatic cancer
OT  - Vaccine
EDAT- 2019/11/05 06:00
MHDA- 2020/04/28 06:00
CRDT- 2019/11/03 06:00
PHST- 2019/08/29 00:00 [received]
PHST- 2019/10/04 00:00 [revised]
PHST- 2019/10/09 00:00 [accepted]
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/11/03 06:00 [entrez]
AID - S0344-0338(19)31840-0 [pii]
AID - 10.1016/j.prp.2019.152691 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2019 Dec;215(12):152691. doi: 10.1016/j.prp.2019.152691. Epub 
      2019 Oct 17.