PMID- 31678012 OWN - NLM STAT- MEDLINE DCOM- 20210913 LR - 20210913 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 19 IP - 3 DP - 2020 May TI - Test-retest reliability, minimal detectable change and minimal clinically important differences in modified shuttle walk test in children and adolescents with cystic fibrosis. PG - 442-448 LID - S1569-1993(19)30915-4 [pii] LID - 10.1016/j.jcf.2019.10.007 [doi] AB - BACKGROUND: In youths with cystic fibrosis (CF) the modified shuttle walk test (MSWT) has been shown to be useful for assessing exercise tolerance; however, no studies to date have evaluated the reliability of MSWT, the minimal detectable change (MDC) and the minimal clinically important differences (MCID) for the MSWT distance for children and adolescents with CF. METHODS: Test-retest reliability: 35 CF patients and 34 healthy controls performed two MSWTs (separated by 2-4 days). MCID: 33 patients were invited to participate in a 6-week home-based exercise program consisting of 30-60-min sessions, 5 days a week. RESULTS: The test-retest reliability of the MSWT distance for children and adolescents with CF was excellent, obtaining a MDC(90) and MDC(95) of 97.08 m and 115.32 m, respectively. The test-retest reliability also was excellent in healthy controls, founding a MDC(90) and MDC(95) of 69.12 m and 82.11 m, respectively. The ROC curve analysis established (with a sensitivity of 82% and specificity of 76%) that a change of 60 m represented MCID. CONCLUSIONS: The MSWT is a reliable tool to measure of exercise tolerance in children/adolescents with CF and those without CF. We propose a change in the score of at least 97.08 m (MDC(90)) as the most appropriate value for assessing the exercise response of children and adolescents with CF, given that this value exceeds the MCID based on the children's perception. CI - Copyright (c) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. FAU - Del Corral, Tamara AU - Del Corral T AD - Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autonoma de Madrid, Spain; Ciencias del Movimiento, Bioconducta y Estudio del dolor, Centro Superior de Estudios Universitarios La Salle, Universidad Autonoma de Madrid, Spain. Electronic address: tamaradelcorral@gmail.com. FAU - Gomez Sanchez, Alvaro AU - Gomez Sanchez A AD - Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autonoma de Madrid, Spain. Electronic address: agosan@campuslasalle.es. FAU - Lopez-de-Uralde-Villanueva, Ibai AU - Lopez-de-Uralde-Villanueva I AD - Hospital La Paz, Institute for Health Research, (IdiPAZ), Madrid, Spain; Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, Spain. Electronic address: ibai.uralde@gmail.com. LA - eng PT - Journal Article DEP - 20191031 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 SB - IM MH - Adolescent MH - Child MH - *Cystic Fibrosis/diagnosis/epidemiology/physiopathology MH - Exercise/physiology MH - Exercise Tolerance MH - Female MH - Humans MH - Male MH - Minimal Clinically Important Difference MH - Outcome Assessment, Health Care MH - ROC Curve MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Spain/epidemiology MH - Spirometry/methods/statistics & numerical data MH - Walk Test/*methods MH - Walking/*physiology OTO - NOTNLM OT - Children and adolescents OT - Cystic fibrosis OT - Physical activity OT - Pulmonary rehabilitation OT - Shuttle walk test OT - Submaximal exercise testing EDAT- 2019/11/05 06:00 MHDA- 2021/09/14 06:00 CRDT- 2019/11/04 06:00 PHST- 2019/05/31 00:00 [received] PHST- 2019/08/14 00:00 [revised] PHST- 2019/10/01 00:00 [accepted] PHST- 2019/11/05 06:00 [pubmed] PHST- 2021/09/14 06:00 [medline] PHST- 2019/11/04 06:00 [entrez] AID - S1569-1993(19)30915-4 [pii] AID - 10.1016/j.jcf.2019.10.007 [doi] PST - ppublish SO - J Cyst Fibros. 2020 May;19(3):442-448. doi: 10.1016/j.jcf.2019.10.007. Epub 2019 Oct 31.