PMID- 31679094
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1612-9067 (Electronic)
IS  - 1612-9059 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Jan
TI  - Risk of hemorrhage and stricture significantly increases in elderly patients with 
      proton pump inhibitor (PPI)-resistant reflux esophagitis.
PG  - 87-91
LID - 10.1007/s10388-019-00702-y [doi]
AB  - BACKGROUND: To examine the clinical characteristics, including complications, of 
      patients older than 75 years of age with proton pump inhibitor-resistant reflux 
      esophagitis. METHODS: Patients who were resistant to standard-dose proton pump 
      inhibitors were enrolled in the present study. Eligible patients (n = 26) were 
      divided into those who were older (n = 11) and younger (n = 15) than 75 years of 
      age. Clinical characteristics including complications (hemorrhage and stricture), 
      body mass index, the severity of reflux esophagitis, Helicobactor pylori 
      infection, gastric mucosal atrophy, hiatal hernia, kyphosis, and the use of 
      antithrombotic agents were examined. The efficacy of 20 mg vonoprazan for proton 
      pump inhibitor-resistant reflux esophagitis was also investigated. RESULTS: The 
      severity of reflux esophagitis was significantly higher in the elderly group than 
      in the non-elderly group. No other significant differences were observed between 
      the groups. The proportion of patients with hemorrhage was significantly larger 
      in the elderly group than in the non-elderly group. Similarly, the proportion of 
      patients with stricture was significantly larger in the elderly group than in the 
      non-elderly group. Nine out of 10 patients in the elderly group and all patients 
      in the non-elderly group achieved healing after the 4-week administration of 
      20 mg vonoprazan. No significant differences were observed in healing rates 
      between the groups. CONCLUSION: Among patients with proton pump 
      inhibitor-resistant reflux esophagitis, the rates of severe reflux esophagitis 
      and complications (hemorrhage and/or stricture) were significantly higher in 
      elderly patients than in non-elderly patients. Regardless of age, 20 mg 
      vonoprazan was effective for proton pump inhibitor-resistant reflux esophagitis.
FAU - Takenouchi, Nana
AU  - Takenouchi N
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Hoshino, Shintaro
AU  - Hoshino S
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Hoshikawa, Yoshimasa
AU  - Hoshikawa Y
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Tanabe, Tomohide
AU  - Tanabe T
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Koeda, Mai
AU  - Koeda M
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Momma, Eri
AU  - Momma E
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Ishikawa, Yumiko
AU  - Ishikawa Y
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Kawami, Noriyuki
AU  - Kawami N
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Kaise, Mitsuru
AU  - Kaise M
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
FAU - Iwakiri, Katsuhiko
AU  - Iwakiri K
AUID- ORCID: 0000-0002-5558-6104
AD  - Department of Gastroenterology, Nippon Medical School, Graduate School of 
      Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. k-iwa@nms.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20191102
PL  - Japan
TA  - Esophagus
JT  - Esophagus : official journal of the Japan Esophageal Society
JID - 101206627
RN  - 0 
      (1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Sulfonamides)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Constriction, Pathologic/diagnosis/*etiology
MH  - Drug Resistance/*physiology
MH  - Esophagitis, Peptic/*complications/drug therapy
MH  - Female
MH  - Fibrinolytic Agents/adverse effects
MH  - Hemorrhage/diagnosis/*etiology
MH  - Hernia, Hiatal/complications
MH  - Humans
MH  - Kyphosis/complications
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/administration & dosage/therapeutic use
MH  - Pyrroles/administration & dosage/therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sulfonamides/administration & dosage/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bleeding
OT  - Complication
OT  - PPI-resistant reflux esophagitis
OT  - Stricture
OT  - Vonoprazan
EDAT- 2019/11/05 06:00
MHDA- 2021/07/16 06:00
CRDT- 2019/11/04 06:00
PHST- 2019/08/25 00:00 [received]
PHST- 2019/10/27 00:00 [accepted]
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2019/11/04 06:00 [entrez]
AID - 10.1007/s10388-019-00702-y [pii]
AID - 10.1007/s10388-019-00702-y [doi]
PST - ppublish
SO  - Esophagus. 2020 Jan;17(1):87-91. doi: 10.1007/s10388-019-00702-y. Epub 2019 Nov 
      2.