PMID- 31680613
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 22
IP  - 8
DP  - 2020 Aug
TI  - Assessment of treatment outcomes in hyperthyroid cats treated with an orally 
      administered fixed dose of radioiodine.
PG  - 744-752
LID - 10.1177/1098612X19884155 [doi]
AB  - OBJECTIVES: The aims of this study were to describe the treatment outcomes 
      following oral administration of a fixed dose (138 MBq; 3.7 mCi) of radioiodine 
      in hyperthyroid cats and to examine the correlation between total thyroxine (TT4) 
      concentrations before and after treatment. METHODS: This was a retrospective 
      cohort study that documented the TT4 concentration and clinicopathological 
      parameters at the time of diagnosis and after treatment. Logistic regression was 
      used to assess the relationship between TT4 concentrations before and after 
      treatment. The difference in pre- and post-treatment variables between cats that 
      had TT4 concentrations below or within the reference interval (RI) was compared 
      by the Mann-Whitney U-test. RESULTS: Of 161 cats, 133 (82.6%) cats had TT4 
      concentrations within the RI, four (2.5%) cats had TT4 concentrations above the 
      RI and 24 (14.9%) cats had TT4 concentrations below the RI after treatment. The 
      severity of hyperthyroidism at diagnosis, as measured by the percentage of TT4 
      elevation above the upper limit of the RI, had no impact on the odds of cats 
      having low TT4 concentrations after treatment (odds ratio 1.00; 95% confidence 
      interval 0.96-1.05; P = 0.828). CONCLUSIONS AND RELEVANCE: When using an orally 
      administered fixed dose of radioiodine for the treatment of feline 
      hyperthyroidism, TT4 concentrations at diagnosis cannot be used to predict TT4 
      concentrations after treatment. The proportion of cats with TT4 concentrations 
      below the lower limit of the RI after treatment was 14.9%. Further work is 
      required to optimise oral radioiodine dosing to achieve maximal euthyroid 
      outcomes.
FAU - Yu, Lucia
AU  - Yu L
AUID- ORCID: 0000-0003-0911-6811
AD  - Translational Research and Small Animal Clinical Trial Study Group, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, VIC, 
      Australia.
FAU - Lacorcia, Lauren
AU  - Lacorcia L
AUID- ORCID: 0000-0002-1767-6248
AD  - Translational Research and Small Animal Clinical Trial Study Group, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, VIC, 
      Australia.
FAU - Finch, Sue
AU  - Finch S
AUID- ORCID: 0000-0003-4261-0504
AD  - Statistical Consulting Centre, The University of Melbourne, VIC, Australia.
FAU - Johnstone, Thurid
AU  - Johnstone T
AUID- ORCID: 0000-0001-6643-9153
AD  - Translational Research and Small Animal Clinical Trial Study Group, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, VIC, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20191104
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
RN  - 0 (Iodine Radioisotopes)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Cat Diseases/*radiotherapy
MH  - Cats
MH  - Cohort Studies
MH  - Hyperthyroidism/radiotherapy/*veterinary
MH  - Iodine Radioisotopes/*therapeutic use
MH  - Retrospective Studies
MH  - Thyroxine/*analysis
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Hyperthyroidism
OT  - administration
OT  - azotaemia
OT  - iodine
OT  - oral
OT  - treatment outcomes
EDAT- 2019/11/05 06:00
MHDA- 2021/02/17 06:00
CRDT- 2019/11/05 06:00
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2019/11/05 06:00 [entrez]
AID - 10.1177/1098612X19884155 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2020 Aug;22(8):744-752. doi: 10.1177/1098612X19884155. Epub 
      2019 Nov 4.