PMID- 31681206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 10
DP  - 2019
TI  - Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits 
      Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA) Without 
      Inducing Resistance.
PG  - 2341
LID - 10.3389/fmicb.2019.02341 [doi]
LID - 2341
AB  - New options are urgently needed for the treatment of methicillin-resistant 
      Staphylococcus aureus (MRSA) infections. Balsacone C is a new dihydrochalcone 
      extracted from Populus balsamifera that has been reported previously as being 
      active against Staphylococcus aureus. Here, we evaluate the antibacterial 
      activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were 
      obtained from hospitalized patients; these isolates were then characterized for 
      their resistance. Most of these MRSA (>85%) were resistant to penicillin, 
      amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, 
      clindamycin, erythromycin, and cefoxitin as well as being sensitive to linezolid, 
      trimethoprim/sulfamethoxazole, rifampicin, and gentamicin. When tested against 
      all MRSA isolates and various gram-positive bacteria, the antibacterial activity 
      of balsacone C produced a MIC of 3-11.6 mg/mL. We observed no resistant isolates 
      of MRSA (against balsacone C) even after 30 passages. Microscopy fluorescence 
      showed that bacteria cell membrane integrity was compromised by low 
      concentrations of balsacone C. Scanning electron microscope (SEM) confirmed 
      balsacone C-provoked changes in the bacterial cell membrane and we find a 
      dose-dependent release of DNA and proteins. This loss of cellular integrity leads 
      to cell death and suggests a low potential for the development of spontaneous 
      resistance.
CI  - Copyright (c) 2019 Cote, Pichette, Simard, Ouellette, Ripoll, Mihoub, Grimard and 
      Legault.
FAU - Cote, Heloise
AU  - Cote H
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
FAU - Pichette, Andre
AU  - Pichette A
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
AD  - Centre de Recherche sur la Borealie, Universite du Quebec a Chicoutimi, 
      Chicoutimi, QC, Canada.
FAU - Simard, Francois
AU  - Simard F
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
FAU - Ouellette, Marie-Eve
AU  - Ouellette ME
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
FAU - Ripoll, Lionel
AU  - Ripoll L
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
AD  - Centre de Recherche sur la Borealie, Universite du Quebec a Chicoutimi, 
      Chicoutimi, QC, Canada.
FAU - Mihoub, Mouadh
AU  - Mihoub M
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
FAU - Grimard, Doria
AU  - Grimard D
AD  - Laboratoire de Microbiologie, Complexe Hospitalier de la Sagamie, Chicoutimi, QC, 
      Canada.
FAU - Legault, Jean
AU  - Legault J
AD  - Laboratoire d'Analyse et de Separation des Essences Vegetales, Departement des 
      Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, 
      Canada.
AD  - Centre de Recherche sur la Borealie, Universite du Quebec a Chicoutimi, 
      Chicoutimi, QC, Canada.
LA  - eng
PT  - Journal Article
DEP - 20191015
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC6804428
OTO - NOTNLM
OT  - MRSA
OT  - Populus balsamifera
OT  - Staphylococcus aureus
OT  - antibiotic
OT  - balsacone
OT  - buds
EDAT- 2019/11/05 06:00
MHDA- 2019/11/05 06:01
PMCR- 2019/10/15
CRDT- 2019/11/05 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/09/25 00:00 [accepted]
PHST- 2019/11/05 06:00 [entrez]
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2019/11/05 06:01 [medline]
PHST- 2019/10/15 00:00 [pmc-release]
AID - 10.3389/fmicb.2019.02341 [doi]
PST - epublish
SO  - Front Microbiol. 2019 Oct 15;10:2341. doi: 10.3389/fmicb.2019.02341. eCollection 
      2019.