PMID- 31681306
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20240421
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Dendritic Cells as Sensors, Mediators, and Regulators of Ischemic Injury.
PG  - 2418
LID - 10.3389/fimmu.2019.02418 [doi]
LID - 2418
AB  - Dendritic cells (DCs) are highly specialized, bone marrow (BM)-derived 
      antigen-processing and -presenting cells crucial to the induction, integration 
      and regulation of innate, and adaptive immunity. They are stimulated by 
      damage-associated molecular patterns (DAMPS) via pattern recognition receptors to 
      promote inflammation and initiate immune responses. In addition to residing 
      within the parenchyma of all organs as part of the heterogeneous mononuclear 
      phagocyte system, DCs are an abundant component of the inflammatory cell 
      infiltrate that appears in response to ischemia reperfusion injury (IRI). They 
      can play disparate roles in the pathogenesis of IRI since their selective 
      depletion has been found to be protective, deleterious, or of no benefit in mouse 
      models of IRI. In addition, administration of DC generated and manipulated ex 
      vivo can protect organs from IRI by suppressing inflammatory cytokine production, 
      limiting the capacity of DCs to activate NKT cells, or enhancing regulatory T 
      cell function. Few studies however have investigated specific signal transduction 
      mechanisms underlying DC function and how these affect IRI. Here, we address 
      current knowledge of the role of DCs in regulation of IRI, current gaps in 
      understanding and prospects for innovative therapeutic intervention at the 
      biological and pharmacological levels.
CI  - Copyright (c) 2019 Dai, Thomson and Rogers.
FAU - Dai, Helong
AU  - Dai H
AD  - Department of Urological Organ Transplantation, The Second Xiangya Hospital of 
      Central South University, Changsha, China.
AD  - Clinical Research Center for Organ Transplantation of Hunan Province, Changsha, 
      China.
FAU - Thomson, Angus W
AU  - Thomson AW
AD  - Department of Surgery, Thomas E. Starzl Transplantation Institute, University of 
      Pittsburgh School of Medicine, Pittsburgh, PA, United States.
AD  - Department of Immunology, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, United States.
FAU - Rogers, Natasha M
AU  - Rogers NM
AD  - Department of Surgery, Thomas E. Starzl Transplantation Institute, University of 
      Pittsburgh School of Medicine, Pittsburgh, PA, United States.
AD  - Center for Transplant and Renal Research, Westmead Institute for Medical 
      Research, Westmead, NSW, Australia.
AD  - Renal Division, Westmead Hospital, Westmead, NSW, Australia.
AD  - Westmead Clinical School, University of Sydney, Camperdown, NSW, Australia.
LA  - eng
GR  - R01 AI118777/AI/NIAID NIH HHS/United States
GR  - R21 AI137799/AI/NIAID NIH HHS/United States
GR  - U19 AI131453/AI/NIAID NIH HHS/United States
GR  - U01 AI136779/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191015
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Communication
MH  - Cell Plasticity/immunology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - *Disease Susceptibility
MH  - Humans
MH  - Hypoxia/genetics/immunology/metabolism
MH  - *Immunity
MH  - *Immunomodulation
MH  - Ischemia/*etiology/*metabolism
MH  - Ischemic Preconditioning
MH  - Organ Specificity
MH  - Phenotype
MH  - Reperfusion Injury/etiology/metabolism/pathology
PMC - PMC6803430
OTO - NOTNLM
OT  - dendritic cells
OT  - heart
OT  - ischemic injury
OT  - kidney
OT  - liver
EDAT- 2019/11/05 06:00
MHDA- 2020/11/11 06:00
PMCR- 2019/01/01
CRDT- 2019/11/05 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/09/27 00:00 [accepted]
PHST- 2019/11/05 06:00 [entrez]
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.02418 [doi]
PST - epublish
SO  - Front Immunol. 2019 Oct 15;10:2418. doi: 10.3389/fimmu.2019.02418. eCollection 
      2019.