PMID- 31681857
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 2398-502X (Print)
IS  - 2398-502X (Electronic)
IS  - 2398-502X (Linking)
VI  - 4
DP  - 2019
TI  - Expert voices and equal partnerships: establishing Controlled Human Infection 
      Models (CHIMs) in Vietnam.
PG  - 143
LID - 10.12688/wellcomeopenres.15337.1 [doi]
LID - 143
AB  - The number of controlled human infection models (CHIMs) conducted worldwide has 
      increased considerably in recent years, although few have been conducted in low 
      and middle-income countries (LMICs), where infectious diseases have the greatest 
      burden. Recently Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh 
      City (HCMC) started developing CHIM research proposals motivated by the need to 
      develop a clearer and more grounded understanding of the issues surrounding the 
      conduct of CHIMs in LMICs. To explore initial perceptions and barriers to 
      conducting CHIMs in Vietnam, OUCRU researchers conducted a set of key stakeholder 
      interviews early in 2018 and held a CHIM workshop in HCMC in March 2018. This 
      paper summarizes the discussions from the workshop and outlines a way forward for 
      conducting CHIMs in Vietnam.
CI  - Copyright: (c) 2019 Kestelyn E et al.
FAU - Kestelyn, Evelyne
AU  - Kestelyn E
AUID- ORCID: 0000-0002-5728-0918
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
FAU - Le Phuong, Chi
AU  - Le Phuong C
AUID- ORCID: 0000-0003-0312-292X
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
FAU - Ilo Van Nuil, Jennifer
AU  - Ilo Van Nuil J
AUID- ORCID: 0000-0002-5167-5505
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
FAU - Dong Thi, Hoai Tam
AU  - Dong Thi HT
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
FAU - Minh Nguyen, Nguyet
AU  - Minh Nguyen N
AUID- ORCID: 0000-0002-5960-7849
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
FAU - Dinh The, Trung
AU  - Dinh The T
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
FAU - Chambers, Mary
AU  - Chambers M
AUID- ORCID: 0000-0003-0535-3895
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
FAU - Simmons, Cameron P
AU  - Simmons CP
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
AD  - Institute for Vector-Borne Disease, Monash University, Clayton, VIC 3800, 
      Australia.
FAU - Nguyen Trong, Toan
AU  - Nguyen Trong T
AD  - Pasteur Institute, Ho Chi MInh City, Vietnam.
FAU - Nguyen The, Dung
AU  - Nguyen The D
AD  - Department of Infectious Diseases, School of Medicine, Vietnam National 
      University, Ho Chi Minh City, Vietnam.
FAU - Phuong, Le Truc
AU  - Phuong LT
AD  - Nguyen Tri Phuong Hospital, Ho Chi Minh City, Vietnam.
FAU - Do Van, Dung
AU  - Do Van D
AUID- ORCID: 0000-0001-6872-3481
AD  - University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Duc Anh, Dung
AU  - Duc Anh D
AD  - University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Nguyen Van, Vinh Chau
AU  - Nguyen Van VC
AUID- ORCID: 0000-0003-4668-1019
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
FAU - Baker, Stephen
AU  - Baker S
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
FAU - Wills, Bridget
AU  - Wills B
AUID- ORCID: 0000-0001-9086-8804
AD  - Oxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, 
      Vietnam.
AD  - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
CN  - OUCRU Controlled Human Infection Models workshop and focus group participants
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20190925
PL  - England
TA  - Wellcome Open Res
JT  - Wellcome open research
JID - 101696457
PMC - PMC6820821
OTO - NOTNLM
OT  - CHIM
OT  - Controlled human infection model
OT  - Human Challenge Studies
OT  - vaccine
OT  - workshop report
COIS- No competing interests were disclosed.
EDAT- 2019/11/05 06:00
MHDA- 2019/11/05 06:01
PMCR- 2019/09/25
CRDT- 2019/11/05 06:00
PHST- 2019/09/02 00:00 [accepted]
PHST- 2019/11/05 06:00 [entrez]
PHST- 2019/11/05 06:00 [pubmed]
PHST- 2019/11/05 06:01 [medline]
PHST- 2019/09/25 00:00 [pmc-release]
AID - 10.12688/wellcomeopenres.15337.1 [doi]
PST - epublish
SO  - Wellcome Open Res. 2019 Sep 25;4:143. doi: 10.12688/wellcomeopenres.15337.1. 
      eCollection 2019.