PMID- 31686773
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 13
DP  - 2019
TI  - Variable structure and function relationship of compressive optic neuropathy at 
      the time of diagnosis.
PG  - 1599-1608
LID - 10.2147/OPTH.S215115 [doi]
AB  - PURPOSE: To illustrate the structure-function relationship of compressive optic 
      neuropathy (CON) at the time of diagnosis. PATIENTS AND METHODS: Thirty-two eyes 
      of newly diagnosed suprasellar CON and 60 healthy eyes were included in the 
      study. The peripapillary retinal nerve fiber layer (RNFL) thickness and macular 
      ganglion cell-inner plexiform layer (GCIPL) thickness were obtained using Cirrus 
      spectral domain optical coherence tomography (SD-OCT). CON eyes were stratified 
      based on the similar degree and pattern of both RNFL and GCIPL. RESULTS: From 32 
      eyes of newly diagnosed suprasellar CON eyes, 27 eyes had a predominantly nasal 
      hemiretina thinning of macular GCIPL, 4 eyes showed a generalized macular 
      thinning, and 1 eye showed a predominantly superior macular thinning. The 
      corresponding temporal peripapillary RNFL thinning with nasal hemiretina GCIPL 
      thinning were inconsistently manifested. Structure-function analysis of 
      stratified CON eyes with similar thinning profiles showed that a range rather 
      than a fixed value of visual field loss based on mean deviation (MD) index was 
      associated to each thinning profile. The maximal limit of visual field loss range 
      was ubiquitously nonrestricted to any structural thinning profile. While the 
      minimal limit of the associated MD range was gradually reduced from 0 to about 
      -16.0 dB, the nasal hemiretina macular GCIPL thinning was the only manifestation 
      and decreased from 75 to 45 microm. However, the different degrees of temporal 
      hemiretina macular GCIPL and superior-inferior peripapillary RNFL thinning were 
      only seen in 10 of 32 eyes of which their nasal hemiretina GCIPL and temporal 
      RNFL thinning had reached significant thinning. Interestingly when present, the 
      minimal limit of associated MD range continued to decrease from -16.0 to -32.0 
      dB. CONCLUSION: CON eyes can present with variable structure and function 
      relationship at the time of diagnosis. Using structural parameters at the time of 
      diagnosis to predict the prognosis should be used with caution.
CI  - (c) 2019 Laowanapiban et al.
FAU - Laowanapiban, Poramaet
AU  - Laowanapiban P
AD  - Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
AD  - Ophthalmology Service, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, 
      Thailand.
FAU - Chirapapaisan, Niphon
AU  - Chirapapaisan N
AD  - Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Kemahayung, Sumitra
AU  - Kemahayung S
AD  - Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Srikong, Mathuwan
AU  - Srikong M
AD  - Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20190822
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC6709828
OTO - NOTNLM
OT  - macular ganglion cell-inner plexiform layer
OT  - optical coherence tomography
OT  - peripapillary retinal nerve fiber layer
OT  - suprasellar mass
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/11/07 06:00
MHDA- 2019/11/07 06:01
PMCR- 2019/08/22
CRDT- 2019/11/06 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/11/06 06:00 [entrez]
PHST- 2019/11/07 06:00 [pubmed]
PHST- 2019/11/07 06:01 [medline]
PHST- 2019/08/22 00:00 [pmc-release]
AID - 215115 [pii]
AID - 10.2147/OPTH.S215115 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2019 Aug 22;13:1599-1608. doi: 10.2147/OPTH.S215115. eCollection 
      2019.